NHLRC1 antibody
Principal name
NHLRC1 antibody
Alternative names for NHLRC1 antibody
EPM2B, NHL repeat-containing protein 1
Ncbi ID
9606, NP_940988.2, NM_175340, NM_199236, NM_198586, NP_780549.1
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF)
Background of NHLRC1 antibody
Progressive myoclonic epilepsy type 2 (EPM2), also called Lafora disease, is an autosomal recessive disease characterized by grand mal seizures and/or myoclonus at about 15 years of age. Rapid and severe mental deterioration follows, often with psychotic features. Survival is less than 10 years after onset. Starch-like, endoplasmic reticulum-associated polyglucosans, called Lafora bodies, can be observed in brain, muscle, liver and heart. One cause of Lafora disease is due to mutations in NHLRC1, the gene encoding Malin. Forty-nine different mutations in NHLRC1 have been shown to cause EPM2. Malin, also called NHL repeat-containing protein 1 ( NHLRC1), is a single subunit E3 ubiquitin ligase, containing 6 NHL repeats and 1 RING-type zinc finger. Malin’s RING domain is responsible for its ability to mediate ubiquitination. Malin interacts with and polyubiquitinates Laforin, a protein also implicated in EPM2. Malin localizes to the endoplasmic reticulum and, to a lesser extent, in the nucleus. Malin is expressed in brain, cerebellum, spinal cord, medulla, heart, liver, skeletal muscle and pancreas.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| 73-128 | NHLRC1 antibody |
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Mouse | IgG1 | N85/18 | Supernatant | Hu, Ms, Rt | ICC/IF, WB |
5 ml /
€490.00
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| Antibodies Incorporated | |||||||
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| 75-128 | NHLRC1 antibody |
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 |
Mouse | IgG1 | N85/18 | Purified | Hu, Ms, Rt | ICC/IF, WB |
0.1 ml /
€570.00
|
| Antibodies Incorporated | |||||||
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| AM60046PU-N | NHLRC1 (N-term) antibody |
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Mouse | IgG1 | S85-18 | Purified | Hu | ICC/IF, WB |
0.1 mg /
€410.00
|
| OriGene Technologies GmbH | |||||||
Rat Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RR213175L2V | Lenti ORF particles, Nhlrc1 (GFP-tagged ORF) - Rat NHL repeat containing 1 (Nhlrc1), 200 uL, >10^7 TU/mL |
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200 µl /
€930.00
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|
| OriGene Technologies, Inc. | ||
| RR213175L1V | Lenti ORF particles, Nhlrc1 (Myc-DDK-tagged ORF) - Rat NHL repeat containing 1 (Nhlrc1), 200 uL, >10^7 TU/mL |
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200 µl /
€830.00
|
|
| OriGene Technologies, Inc. | ||