NOB1 antibody

Background of NOB1 antibody

In yeast, over 200 protein and R cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rR transcript into the mature 18S, 5.8S, and 25S rRs, folding of the rR, and binding of ribosomal proteins and 5S R. Nob1 is involved in pre-rR processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rR intermediate at cleavage site D to produce the mature 18S rR (Laman and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010]. Transcript Variant: This variant (2) lacks an interl exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mR decay (NMD). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additiol publications. ##Evidence-Data-START## Transcript exon combition :: BG386829.1 [ECO:0000332] Rseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.