PKN2 antibody
Principal name
PKN2 antibody
Alternative names for PKN2 antibody
PRK2, PRKCL2, Protein kinase C-like 2, Serine/threonine-protein kinase N2, Protein-kinase C-related kinase 2
Ncbi ID
9606, NM_006256, NP_006247.1, NP_006247, NP_848769.2, BC052073, NM_178654
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)
Background of PKN2 antibody
Pkn2 is a PKC-related serine/threonine-protein kise and Rho/Rac effector protein that participates in specific sigl transduction responses in the cell. It plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation sigling processes. Pkn2 phosphorylates CTTN in hyaluron-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin, phosphorylates HDAC5, therefore lead to impair HDAC5 import. It is a direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells and is required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. It stimulates FYN kise activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation, regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion, inhibits Akt pro-survival-induced kise activity. It mediates Rho protein-induced transcriptiol activation via the c-fos serum response factor (SRF).
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- Highly Validated (1)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| AM06663SU-N | PKN2 antibody |
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Mouse | IgG1 | 1D1 | Ascites | Hu, Mky, Ms, Rt | E, P, WB |
0.1 ml /
€410.00
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| OriGene Technologies GmbH | |||||||
 +5 additional images |
Highly validated antibody! |
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| TA308478 | PKN2 antibody |
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| Rabbit polyclonal antibody to protein kinase N2 (protein kinase N2) | |||||||
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Rabbit | IgG | Aff - Purified | Hu | ICC/IF, WB |
0.1 ml /
€415.00
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|
| OriGene Technologies, Inc. | |||||||
| +2 additional images |
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Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP320989 | PKN2 |
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| Recombinant protein of human protein kinase N2 (PKN2) | |||||
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Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€788.00
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|
| OriGene Technologies, Inc. | |||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY416764 | PKN2 overexpression lysate |
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0.1 mg /
€495.00
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|
| OriGene Technologies, Inc. |
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR211351L2V | Lenti ORF particles, Pkn2 (GFP-tagged) - Mouse protein kinase N2 (cDNA clone MGC:62484 IMAGE:6400440), 200 uL, >10^7 TU/mL |
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200 µl /
€1,470.00
|
|
| OriGene Technologies, Inc. | ||
| MR211351L1V | Lenti ORF particles, Pkn2 (Myc-DDK-tagged) - Mouse protein kinase N2 (cDNA clone MGC:62484 IMAGE:6400440), 200 uL, >10^7 TU/mL |
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200 µl /
€1,330.00
|
|
| OriGene Technologies, Inc. | ||