PLA2G1B antibody
Principal name
PLA2G1B antibody
Alternative names for PLA2G1B antibody
PLA2G1B, PLA2, PLA2A, PPLA2, Phospholipase A2, Group IB phospholipase A2, Phosphatidylcholine 2-acylhydrolase 1B
SwissProt ID
P00592 (Pig), P00593 (Bovin), P00594 (Horse), P04054 (Human), P04055 (Rat), P06596 (Canfa), P14419 (Sheep), Q7M334 (Rabit), Q9Z0Y2 (Mouse)
Ncbi ID
NP_000919, 9606, NP_001004037, NP_000919.1, NM_000928, NP_035237.1, NM_011107, NM_031585
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Dot blot (Dot), Immunodiffusion (ID), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Radioimmunoassay (R)
Background of PLA2G1B antibody
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including prostaglandins and leukotrienes. The same reaction also produces lysophosholipids, which represent another class of lipid mediators. The secretory PLA2 (sPLA2) family, in which 10 isozymes have been identified, consists of low-molecular weight, Ca2+-requiring secretory enzymes that have been implicated in a number of biological processes, such as modification of eicosanoid generation, inflammation, and host defense. This enzyme has been proposed to hydrolyze phosphatidylcholine (PC) in lipoproteins to liberate lyso-PC and free fatty acids in the arterial wall, thereby facilitating the accumulation of bioactive lipids and modified lipoproteins in atherosclerotic foci. In mice, sPLA2 expression significantly influences HDL particle size and composition and demonstrate that an induction of sPLA2 is required for the decrease in plasma HDL cholesterol in response to inflammatory stimuli. Instillation of bacteria into the bronchi was associated with surfactant degradation and a decrease in large:small ratio of surfactant aggregates in rats.
General readings
Kolko M, Christoffersen NR, Varoqui H, Bazan NG.
Expression and induction of secretory phospholipase A2 group IB in brain.
Mol Neurobiol. 2005 Nov;25(7):1107-22.
PMID: 16392040.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA302575 | PLA2G1B (C-term) antibody |
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| Goat Polyclonal Antibody against PLA2G1B | |||||||
 |
Goat | Aff - Purified | Can, Hu | WB |
0.1 mg /
€360.00
|
||
| OriGene Technologies, Inc. | |||||||
| AP31908PU-N | PLA2G1B antibody |
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 |
Rabbit | Purified | Hu | E, WB |
0.1 mg /
€450.00
|
||
| OriGene Technologies GmbH | |||||||
Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP316089 | PLA2G1B |
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| Recombinant protein of human phospholipase A2, group IB (pancreas) (PLA2G1B) | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
| PA520X | PLA2G1B (His-tagged Fusion Protein) |
||||
 |
Human | Purified | > 95 % > 95% | E. coli |
0.1 mg /
€490.00
|
| OriGene Technologies GmbH | |||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY400342 | PLA2G1B overexpression lysate |
|
|
0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. |
Rat Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RR207675L2V | Lenti ORF particles, Pla2g1b (GFP-tagged ORF) - Rat phospholipase A2, group IB, pancreas (Pla2g1b), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€930.00
|
|
| OriGene Technologies, Inc. | ||
| RR207675L1V | Lenti ORF particles, Pla2g1b (Myc-DDK-tagged ORF) - Rat phospholipase A2, group IB, pancreas (Pla2g1b), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€830.00
|
|
| OriGene Technologies, Inc. | ||