PPAPDC1B antibody
Principal name
PPAPDC1B antibody
Alternative names for PPAPDC1B antibody
DPPL1, HTPAP, Phosphatidate phosphatase PPAPDC1B, Phosphatidic acid phosphatase type 2 domain-containing protein 1B
Ncbi ID
9606, NP_001096029, NP_001096029.1, NM_032483, NM_001102560, NP_082276.1
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)
Background of PPAPDC1B antibody
Phosphatidate phosphatase (PAP) plays important role in lipid-signaling metabolism in eukaryotic cells. Two distinct types of PAP (PAP1 and PAP2) activity have been distinguished by their subcellular localization and differential sensitivity to N-ethylmaleimide (NEM) and Mg2+. A yeast diacylglycerol pyrophosphate (DGPP) phosphatase (DPP1) and mammalian DGPP phosphatase (PAP2) have been identified as Mg2+-independent and NEM-insensitive membrane-associated. PPAPDC1A (also known as DPPL2) and PPAPDC1B (DPPL1) form a novel type of Mg2+-independent and NEM-sensitive mammalian phosphatidate phosphatase showing broad substrate specificity. Knockdown experiments indicated that this protein is involved with multiple cell signaling pathways, including the JAK-Stat3, MAP kinase, and PKC pathways. PPAPDC1B may also potentiate the estrogen receptor pathway by down-regulating DUSP22.
General readings
Takeuchi,M., (2007) Gene 399 (2), 174-180
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA306885 | PPAPDC1B antibody |
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| Rabbit Polyclonal PPAPDC1B Antibody | |||||||
 |
Rabbit | IgG | Aff - Purified | Hu, Ms | E, WB |
0.1 mg /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
| AP23498PU-N | PPAPDC1B (N-term) antibody |
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 |
Rabbit | Hu, Ms | E, P, WB |
50 µg /
€425.00
|
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| OriGene Technologies GmbH | |||||||
 +1 additional image |
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Lysates
| Catalog No. | ||
|---|---|---|
| LY410110 | PPAPDC1B overexpression lysate |
|
 |
0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. | ||
| LY420157 | PPAPDC1B overexpression lysate |
|
|
0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. | ||
| LY426181 | PPAPDC1B overexpression lysate |
|
|
0.1 mg /
€315.00
|
|
| OriGene Technologies, Inc. |