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PRDM2 antibody

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Principal name

PRDM2 antibody

Alternative names for PRDM2 antibody

PR domain zinc finger protein 2, KMT8, RIZ1, RIZ2, MTB-ZF, HUMHOXY1, Retinoblastoma protein-interacting zinc finger protein, MTE-binding protein, GATA-3-binding protein G3B, Lysine N-methyltransferase 8

SwissProt ID

Q13029 (Human), Q63755 (Rat)

Gene ID

7799 (PRDM2), 313678 (Prdm2)

Ncbi ID

9606, 10116, 5874, NM_001135610, NP_001129082, NP_001007258.1, NM_001007257

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ChIP assay (ChIP), Paraffin Sections (P)

Background of PRDM2 antibody

Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.

PAB2383 - PRDM2
Immunocytochemical analysis of Prdm2 in adenovirus-transduced tumor cells. Established HCT116 xenograft tumors at day 2 after infection of AdRIZ1, Adnull, or buffer alone were processed for RIZ1 in situ detection ( TUNEL ) analysis.
PAB2383 - PRDM2
Rat B50 brain tumor cell extracts were immunoprecipitated with Prdm2 polyclonal antibody ( Cat # PAB2383 ) or preimmune.
MAB1151 - PRDM2
Western blot analysis of PRDM2 monoclonal antibody, clone 33AT1045 ( Cat # MAB1151 ) in lysate from transformed cells. Lane A : mock plasmid, Lane B : PRDM2 [1-347]-encoding plasmid. PRDM2 [1-347] ( arrow ) was detected using purified monoclonal antibody. Secondary HRP-anti-mouse was used for signal visualization with chemiluminescence.
AM11041PU-N - PRDM2
Figure 1. Western blot analysis of anti-PRDM2 Mab (Cat. #AM11041P) in lysate from transformed cells. Lane A: mock plasmid, Lane B: PRDM2[1-347]-encoding plasmid. PRDM2[1-347] (arrow) was detected using purified Mab. Secondary HRP-anti-mouse was used for signal visualization with chemiluminescence.
AP11193PU-N - PRDM2
Immunohistochemical analysis of RIZ1 in adenovirus-transduced tumor cells. Established HCT116 xenograft tumors at day 2 after infection of AdRIZ1, Adnull, or buffer alone were processed for RIZ1 in situ detection (TUNEL) analysis.
AP11193PU-N - PRDM2
Rat B50 brain tumor cell extracts were immunoprecipitated with RIZ antibody (cat# AP11193PU-N) or preimmune.
TP327715 - PRDM2

11 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PRDM2 antibody
  Rabbit Polyclonal Anti-PRDM2 Antibody  
PRDM2 Rabbit IgG Purified Hu E, P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

PRDM2 (1-347) antibody
Figure 1. Western blot analysis of anti-PRDM2 Mab (Cat. #AM11041P) in lysate from transformed cells. Lane A: mock plasmid, Lane B: PRDM2[1-347]-encoding plasmid. PRDM2[1-347] (arrow) was detected using purified Mab. Secondary HRP-anti-mouse was used for signal visualization with chemiluminescence. Mouse IgG1 33AT1045 Purified Hu, Ms WB
0.4 ml / €415.00
  OriGene Technologies GmbH

PRDM2 antibody
Immunohistochemical analysis of RIZ1 in adenovirus-transduced tumor cells. Established HCT116 xenograft tumors at day 2 after infection of AdRIZ1, Adnull, or buffer alone were processed for RIZ1 in situ detection (TUNEL) analysis. Rabbit Ig Purified Hu, Ms, Rt IP, P, WB
0.4 ml / €415.00
  OriGene Technologies GmbH
+1 additional image

CRISPR

Catalog No. Species Donor Vector  

PRDM2 - human gene knockout kit via CRISPR
PRDM2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PRDM2 - human gene knockout kit via CRISPR
PRDM2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PRDM2 - human gene knockout kit via CRISPR
PRDM2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PRDM2 - human gene knockout kit via CRISPR
PRDM2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PRDM2 (transcript variant 4)
  Recombinant protein of human PR domain containing 2, with ZNF domain (PRDM2), transcript variant 4  
PRDM2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.		 HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.
 

Lysates

Catalog No.    

PRDM2 overexpression lysate
PRDM2 overexpression lysate  
0.1 mg / €315.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PRDM2 (mGFP-tagged)-Human PR domain containing 2, with ZNF domain (PRDM2), transcript variant 3, 200 uL, >10^7 TU/mL
Lenti ORF particles, PRDM2 (mGFP-tagged)-Human PR domain containing 2, with ZNF domain (PRDM2), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €2,680.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, PRDM2 (Myc-DDK-tagged)-Human PR domain containing 2, with ZNF domain (PRDM2), transcript variant 3, 200 uL, >10^7 TU/mL
Lenti ORF particles, PRDM2 (Myc-DDK-tagged)-Human PR domain containing 2, with ZNF domain (PRDM2), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €2,420.00
  OriGene Technologies, Inc.
 

11 Item(s)

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11 products - FILTER YOUR RESULTS!

Available Filters

Product Type
  1. CRISPR (4)
  2. Human Lenti ORF Particle (2)
  3. Lysate (1)
  4. Primary Antibody (3)
  5. Protein | Growth Factor (1)
Clonality
  1. Polyclonal (2)
  2. Monoclonal (1)
Target
  1. PRDM2 (4)
Property
  1. 1-347 (1)
Reactivity
  1. Human (Hu) (3)
  2. Mouse (Ms) (2)
  3. Rat (Rt) (1)
Applications
  1. Western blot / Immunoblot (WB) (3)
  2. Paraffin Sections (P) (2)
  3. Enzyme Immunoassay (E) (1)
  4. Immunoprecipitation (IP) (1)
Presentation
  1. Purified (3)
Host
  1. Rabbit (2)
  2. Mouse (1)
Images
  1. 1 image (3)
Images: Applications
  1. Immunoprecipitation (IP) (1)
  2. Paraffin Sections (P) (1)
  3. Western blot / Immunoblot (WB) (1)
Species (Protein)
  1. Human (1)
Source
  1. HEK293 cells (1)
Species (CRISPR)
  1. Human (4)
Donor Vector
  1. GFP-Puro (1)
  2. Luciferase-Puro (1)
  3. RFP-BSD (1)
  4. mBFP-Neo (1)
Manufacturer
  1. OriGene Technologies (11)
Service
  • OriGene Technologies GmbH
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  • D-32052 Herford
  • Germany
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