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PTX3 antibody

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Principal name

PTX3 antibody

Alternative names for PTX3 antibody

TNFAIP5, TSG14, TSG-14, Pentraxin-related protein PTX3, Pentaxin-related protein PTX3, Tumor necrosis factor alpha-induced protein 5, TNF alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein

SwissProt ID

P26022 (Human), P48759 (Mouse), Q0VCG9 (Bovin)

Gene ID

5806 (PTX3), 19288 (Ptx3)

Ncbi ID

9606, NP_002843, NP_033013.3, NP_002843.2, NM_002852, NM_008987

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Por (Porcine), Can (Canine)

Available hosts

Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Paraffin Sections (P), Immunoprecipitation (IP), Frozen Sections (C), Functional assay (FN), Immunohistochemistry (IHC)

Background of PTX3 antibody

PTX3 is an acute-phase glycoprotein of ~45 kDa with glycosylation accounting for about 10% of its molecular weight. PTX3 has a complex oligomeric structure with protomers linked to each other by disulfide bonds. PTX3 expression is triggered by inflammatory cytokines, resulting in higher levels of circulating PTX3. Several cell types have been reported to produce PTX3, namely macrophages, endothelial cells, neutrophils and synoviocytes. PTX3 is involved in host defense against pathogen infection, in the regulation of the scavenger activity of macrophages and dendritic cells, and in modulation of complement activity by binding to C1q. Furthermore, PTX3 has been implicated in matrix deposition of cumulus cells. Moreover, PTX3 interacts with other biologically active molecules, causing their functional blockade. This has been demonstrated for fibroblast growth factor-2 (FGF-2), for which PTX3 acts as an inhibitor, leading to inhibition of angiogenesis. PTX3, like other pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP), binds apoptotic cells and debris. PTX3 is useful as an early indicator of myocyte irreversible injury in ischemic cardiomyopathy. PTX3 is not only involved in inflammatory vessel diseases related to atherosclerosis, but also in pre-eclampsia and systemic small vessel ANCA-associated vasulitis, in which neutrophils are key players. The relationship between tissue damage and pentraxin generation is stringent in acute injuries. PTX3 tunes self-non-self discrimination and tissue repair due to the recognition of diverse ligands by PTX3 and through regulation of effector pathways.

General readings

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253 (2010).
Yilmaz, M.I., et al. Clin J Am Soc Nephrol 5(7):1174-1181 (2010).
Haverkamp, M.H., et al. Int. J. Pediatr. Otorhinolaryngol. 74(7):752-754 (2010).
Hollan, I., et al. Arthritis Care Res (Hoboken) 62(3):378-385 (2010).
Sciacca, P., et al. Front Biosci (Elite Ed) 2, 805-809 (2010).

H00005806-M01 - PTX3
PTX3 monoclonal antibody (M01), clone 5B7. Western Blot analysis of PTX3 expression in PC-12(Cat # L012V1 ).
H00005806-M01 - PTX3
PTX3 monoclonal antibody (M01), clone 5B7. Western Blot analysis of PTX3 expression in NIH/3T3 ( Cat # L018V1 ).
H00005806-M01 - PTX3
Detection limit for recombinant GST tagged PTX3 is approximately 0.3ng/ml as a capture antibody.
H00005806-M02 - PTX3
Immunofluorescence of monoclonal antibody to PTX3 on HeLa cell. [antibody concentration 10 ug/ml]
H00005806-M02 - PTX3
PTX3 monoclonal antibody (M02), clone 2B10. Western Blot analysis of PTX3 expression in U-2 OS ( Cat # L022V1 ).
H00005806-M02 - PTX3
PTX3 monoclonal antibody (M02), clone 2B10. Western Blot analysis of PTX3 expression in PC-12 ( Cat # L012V1 ).
H00005806-M02 - PTX3
Detection limit for recombinant GST tagged PTX3 is approximately 0.03ng/ml as a capture antibody.
AR09193PU-L - PTX3
AR09193PU-L - PTX3
Pentraxin 3, 18-381 aa human, His-tagged, recombinant: 15% SDS-PAGE (3 µg)
ARP56498_P050 - PTX3
Human Prostate; prostate; PTX3 antibody - N-terminal region (ARP56498_P050) in Human Prostate cells using Immunohistochemistry
ARP56498_P050 - PTX3
HepG2 Whole Cell; Host: Rabbit. Target Name:PTX3. Sample Tissue:HepG2 Whole Cell. Lane A: Primary Antibody . Lane B: Primary Antibody + Blocking Peptide . Primary Antibody Concentration:1ug/ml. Peptide Concentration: 5ug/ml. Lysate Quantity: 25ug/lane. Gel Concentration: 0.12%.
ARP56498_P050 - PTX3
Human MCF7; WB Suggested Anti-PTX3 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: MCF7 cell lysate; PTX3 antibody - N-terminal region (ARP56498_P050) in Human MCF7 cells using Western Blot
C10482-1 - PTX3
Immunofluorescence analysis of HuvEc cells, using PTX3 Antibody. The picture on the right is treated with the synthesized peptide.
C10482-1 - PTX3
Western blot analysis of extracts from 293 cells, using PTX3 Antibody. The lane on the right is treated with the synthesized peptide.
ARP56497_P050 - PTX3
Transfected 293T; WB Suggested Anti-PTX3 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Transfected 293T; PTX3 antibody - N-terminal region (ARP56497_P050) in Transfected 293T cells using Western Blot
AP53517PU-N - PTX3
Western blot analysis of PTX3 Antibody (Center) Cat.-No AP53517PU-N in A549 cell line lysates (35ug/lane). This demonstrates the PTX3 antibody detected the PTX3 protein (arrow).
CEK1316 - Human PTX3 ELISA Kit
Representative Standard Curve
CEK1549 - Mouse PTX3 ELISA Kit
Representative Standard Curve
TP307922 - PTX3
CPA4501-100ul - PTX3
Western blot analysis of PTX3 expression in SHSY5Y (A); 293T (B); NIH3T3 (C); rat muscle (D) whole cell lysates.
TA314411 - PTX3
Western blot analysis of extracts from 293 cells, using PTX3 antibody.The lane on the right is treated with the synthesized peptide.
TA314411 - PTX3
Immunofluorescence analysis of HUVEC cells, using PTX3 antibody.The picture on the right is treated with the synthesized peptide.
TA342182 - PTX3
WB Suggested Anti-PTX3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Transfected 293T
TA342183 - PTX3
WB Suggested Anti-PTX3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: MCF7 cell lysate
TA342183 - PTX3
Host: Rabbit; Target Name:PTX3; Sample Tissue:HepG2 Whole Cell; Lane A: Primary Antibody; Lane B: Primary Antibody + Blocking Peptide ; Primary Antibody Concentration:1 ug/ml; Peptide Concentration: 5ug/ml; Lysate Quantity: 25ug/lane; Gel Concentration: 0
TA342183 - PTX3
Human prostate
TA351825 - PTX3
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane: Human normal lung tissue, Primary antibody: (PTX3 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
TA351825 - PTX3
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using (PTX3 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
TA351825 - PTX3
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using (PTX3 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

11 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTX3 antibody
  Rabbit polyclonal anti-PTX3 antibody  
Western blot analysis of extracts from 293 cells, using PTX3 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.
+1 additional image

PTX3 antibody
  Rabbit Polyclonal Anti-PTX3 Antibody  
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane: Human normal lung tissue, Primary antibody: (PTX3 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.
+2 additional images

PTX3 antibody
PTX3 Rat IgG2a MNB4 Purified Hu C, E, F, ICC/IF, IP, P, WB
0.1 mg / €390.00
  OriGene Technologies GmbH

PTX3 antibody
PTX3 Rat IgG2b MNB1 Purified Hu C, E, FN, IP, P, WB
0.1 mg / €390.00
  OriGene Technologies GmbH

PTX3 (Center) antibody
Western blot analysis of PTX3 Antibody (Center) Cat.-No AP53517PU-N in A549 cell line lysates (35ug/lane). This demonstrates the PTX3 antibody detected the PTX3 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €415.00
  OriGene Technologies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PTX3
  Recombinant protein of human pentraxin-related gene, rapidly induced by IL-1 beta (PTX3)  
PTX3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.		 HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.
 

ELISA Kits

Catalog No.    

Human PTX3/Pentraxin 3 ELISA Kit
Human PTX3/Pentraxin 3 ELISA Kit  
1 kit / €500.00
  OriGene Technologies, Inc.

Mouse PTX3/Pentraxin 3 ELISA Kit
Mouse PTX3/Pentraxin 3 ELISA Kit  
1 kit / €500.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

PTX3 overexpression lysate
PTX3 overexpression lysate  
0.1 mg / €295.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ptx3 (GFP-tagged) - Mouse pentraxin related gene (Ptx3), 200 uL, >10^7 TU/mL
Lenti ORF particles, Ptx3 (GFP-tagged) - Mouse pentraxin related gene (Ptx3), 200 uL, >10^7 TU/mL  
200 µl / €930.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Ptx3 (Myc-DDK-tagged) - Mouse pentraxin related gene (Ptx3), 200 uL, >10^7 TU/mL
Lenti ORF particles, Ptx3 (Myc-DDK-tagged) - Mouse pentraxin related gene (Ptx3), 200 uL, >10^7 TU/mL  
200 µl / €830.00
  OriGene Technologies, Inc.
 

11 Item(s)

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Product Type
  1. ELISA Kit (2)
  2. Lysate (1)
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  4. Primary Antibody (5)
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  1. Polyclonal (3)
  2. Monoclonal (2)
Target
  1. PTX3 (6)
Property
  1. Center (1)
Reactivity
  1. Human (Hu) (6)
  2. Mouse (Ms) (3)
Applications
  1. Western blot / Immunoblot (WB) (5)
  2. Enzyme Immunoassay (E) (4)
  3. Paraffin Sections (P) (3)
  4. Frozen sections (C) (2)
  5. Immunocytochemistry/​Immunofluorescence (ICC/IF) (2)
  6. Immunoprecipitation (IP) (2)
  7. Flow cytometry (F) (1)
  8. Functional assay (FN) (1)
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  2. Aff - Purified (1)
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  2. 3+ images (1)
Images: Applications
  1. Western blot / Immunoblot (WB) (3)
  2. Immunofluorescence (IF) (1)
  3. IHC (1)
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  1. Human (1)
Source
  1. HEK293 cells (1)
Manufacturer
  1. OriGene Technologies (11)
Service
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