RAF1 antibody
Principal name
RAF1 antibody
Alternative names for RAF1 antibody
C-RAF, Raf-1, cRaf, RAF proto-oncogene serine/threonine-protein kinase
SwissProt ID
A7E3S4 (Bovin), P04049 (Human), P05625 (Chick), P09560 (Xenla), P11345 (Rat), Q99N57 (Mouse)
Ncbi ID
NP_002871.1, NP_002871, 9606, 10116, NP_036771.1, NM_002880.2, NM_029780, NM_012639, NM_002880, NP_084056.1
Available reactivities
Available hosts
Available applications
Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot), ELISA (detection) (E(detection)), Flow Cytometry (F)
Background of RAF1 antibody
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.














































































- Quick-Filters:
- Highly Validated (1)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| AM06729PU-N | RAF1 antibody |
||||||
![]() |
Mouse | IgG1 | 4G4 | Purified | Hu | E, F, P, WB |
0.1 mg /
€410.00
|
| OriGene Technologies GmbH | |||||||
+4 additional images |
Highly validated antibody! |
||||||
| TA309227 | RAF1 antibody |
||||||
| Rabbit Anti-Raf-1 (Ser301) Antibody (Phospho-Specific) | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Rt | WB |
0.1 ml /
€405.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA309228 | RAF1 antibody |
||||||
| Rabbit Anti-Raf-1 (Ser642) Antibody (Phospho-Specific) | |||||||
![]() |
Rabbit | IgG | Purified | Rt | WB |
0.1 ml /
€405.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA313051 | RAF1 antibody |
||||||
| Rabbit polyclonal Raf1 (Ab-341) antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | E, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA313052 | RAF1 antibody |
||||||
| Rabbit polyclonal Raf1 (Ab-621) antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | E, ICC/IF, P, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
+2 additional images |
|||||||
| TA313057 | RAF1 antibody |
||||||
| Rabbit polyclonal C-RAF (Ser642) antibody(Phospho-specific) | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms | E, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA313058 | RAF1 antibody |
||||||
| Rabbit polyclonal C-RAF (Thr269) antibody(Phospho-specific) | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms | E, P |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA313060 | RAF1 antibody |
||||||
| Rabbit polyclonal C-RAF (Ab-642) antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | E, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA318606 | RAF1 antibody |
||||||
| Mouse Anti-Human RAF1/RAF Monoclonal Antibody | |||||||
![]() |
Mouse | IgG1 | Purified | Hu | E |
50 µg /
€425.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA319697 | RAF1 (N-term) antibody |
||||||
| Chicken Polyclonal C-raf Antibody | |||||||
![]() |
Chicken | Aff - Purified | Hu, Ms, Rt | E, WB |
0.1 mg /
€415.00
|
||
| OriGene Technologies, Inc. | |||||||
| TA325786 | RAF1 antibody |
||||||
| Rabbit Polyclonal C-RAF Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA325787 | RAF1 antibody |
||||||
| Rabbit Polyclonal C-RAF (Ser259) Antibody (Phospho-specific) | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA325788 | RAF1 antibody |
||||||
| Rabbit Polyclonal C-RAF (Ser296) Antibody (Phospho-specific) | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA325789 | RAF1 antibody |
||||||
| Rabbit Polyclonal C-RAF (Ser338) Antibody (Phospho-specific) | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA325790 | RAF1 antibody |
||||||
| Rabbit Polyclonal C-RAF (Ser621) Antibody (Phospho-specific) | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA325791 | RAF1 antibody |
||||||
| Rabbit Polyclonal C-RAF Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA347803 | RAF1 antibody |
||||||
| Rabbit Polyclonal Anti-C-RAF Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA349287 | RAF1 antibody |
||||||
| Rabbit Polyclonal Anti-RAF1 Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms, Rt | E, P |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| AM09321PU-N | RAF1 (N-term) antibody |
||||||
![]() |
Mouse | IgG1 | 540 | Purified | Hu | E, WB |
0.5 mg /
€550.00
|
| OriGene Technologies GmbH | |||||||
| AM09322PU-N | RAF1 (N-term) antibody |
||||||
![]() |
Mouse | IgG1 | 863 | Purified | Hu | E, WB |
0.5 mg /
€550.00
|
| OriGene Technologies GmbH | |||||||










































+4 additional images













