RNASEH2A antibody
Principal name
RNASEH2A antibody
Alternative names for RNASEH2A antibody
Ribonuclease H2 subunit A, RNase H2 subunit A, RNAse H2A, RNase HI large subunit, RNASEHI, RNHIA, AGS4, Ribonuclease HI subunit A, Ribonuclease HI large subunit, Aicardi-Goutieres syndrome 4 protein
SwissProt ID
O75792 (Human), P53942 (Yeast), Q10236 (Schpo), Q2TBT5 (Bovin), Q5U209 (Rat), Q9CWY8 (Mouse), Q9SEZ6 (Arath), Q9U6P6 (Caeel), Q9VPP5 (Drome)
Ncbi ID
9606, NP_006388, NP_006388.2, NM_006397, O75792, NP_081463.1, BC029252, NM_027187, NM_001013234
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)
Background of RNASEH2A antibody
Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. The major role of these enzymes is to remove the RNA strand from the RNA/DNA hybrids that form during DNA replication and repair. RNAse H2 is made up of three subunits; all three are required for RNAse activity. Recent evidence has demonstrated that mutations in RNAse H2A or any of the other subunits result in Aicardi-Goutieres syndrome (AGS), a neurological disorder with similar symptoms to viral brain infections including high levels of IFN-alpha in the cerebral spinal fluid. Similar conditions are observed with mutations in TREX1, a single-stranded DNA exonuclease, suggesting that RNAse H2 and TREX1 may have similar roles, and that mutations in any of these genes lead to an accumulation of intracellular nucleic acids, triggering an inflammatory response through activation of the innate immune system.
General readings
Frank P., et al. (1998) Proc Natl Acad Sci USA. 95:12872-12877.Bayliss C D., et al. (2005) Nucleic Acads Res. 33:400-408.
- Quick-Filters:
- Highly Validated (1)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA306706 | RNASEH2A antibody |
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| Rabbit Polyclonal RNAse H2A Antibody | |||||||
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Rabbit | IgG | Aff - Purified | Hu, Ms, Rt | ICC/IF, WB |
0.1 mg /
€415.00
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| OriGene Technologies, Inc. | |||||||
 +3 additional images |
Highly validated antibody! |
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Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP304032 | RNASEH2A |
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| Recombinant protein of human ribonuclease H2, subunit A (RNASEH2A) | |||||
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Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY416666 | RNASEH2A overexpression lysate |
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0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. |
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR203257L2V | Lenti ORF particles, Rnaseh2a (GFP-tagged) - Mouse ribonuclease H2, large subunit (cDNA clone MGC:36700 IMAGE:3666709), 200 uL, >10^7 TU/mL |
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200 µl /
€1,240.00
|
|
| OriGene Technologies, Inc. | ||
| MR204190L2V | Lenti ORF particles, Rnaseh2a (GFP-tagged) - Mouse ribonuclease H2, large subunit (Rnaseh2a), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€930.00
|
|
| OriGene Technologies, Inc. | ||
| MR203257L1V | Lenti ORF particles, Rnaseh2a (Myc-DDK-tagged) - Mouse ribonuclease H2, large subunit (cDNA clone MGC:36700 IMAGE:3666709), 200 uL, >10^7 TU/mL |
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|
200 µl /
€1,110.00
|
|
| OriGene Technologies, Inc. | ||
| MR204190L1V | Lenti ORF particles, Rnaseh2a (Myc-DDK-tagged) - Mouse ribonuclease H2, large subunit (Rnaseh2a), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€830.00
|
|
| OriGene Technologies, Inc. | ||
Rat Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RR202776L2V | Lenti ORF particles, Rnaseh2a (GFP-tagged ORF) - Rat ribonuclease H2, subunit A (Rnaseh2a), 200 uL, >10^7 TU/mL |
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|
200 µl /
€930.00
|
|
| OriGene Technologies, Inc. | ||
| RR202776L1V | Lenti ORF particles, Rnaseh2a (Myc-DDK-tagged ORF) - Rat ribonuclease H2, subunit A (Rnaseh2a), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€830.00
|
|
| OriGene Technologies, Inc. | ||