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ROC2 antibody

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Principal name

ROC2 antibody

Alternative names for ROC2 antibody

GL2-2, Homeobox-leucine zipper protein ROC2, GLABRA 2-like homeobox protein 2, HD-ZIP protein ROC2, Homeodomain transcription factor ROC2, Protein RICE OUTERMOST CELL-SPECIFIC 2

SwissProt ID

Q0J9X2 (Orysj), Q43349 (Arath)

Gene ID

4337074 (Os04g0627000)

Ncbi ID

NP_001053951.1

Available reactivities

Ce (C. elegans), Hu (Human), Ms (Mouse), Ze (Zebrafish)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB)

Background of ROC2 antibody

ROC1 also known as RING-box protein 2, Rbx2, RING finger protein 7, Regulator of cullins 2, CKII betabinding protein 1, and CKBBP1, is a probable component of the SCF (SKP1-CUL1-F-box protein) and the CBC(VHL) (CUL2-elonging BC-VHL) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. ROC2 appears to recruit the E2 ubiquitination enzyme through the RING-type zinc finger in a manner similar to CDC34, and brings it into close proximity to the substrate. ROC2 may play a role in protecting cells from apoptosis induced by redox agents. ROC2 has a cytoplasmic and nuclear localization and is expressed in heart, liver, skeletal muscle and pancreas tissues, and at very low levels in brain, placenta and lung. 1,10-phenanthroline induces ROC2 expression. The RING-type zinc finger domain is essential for ubiquitin ligase activity. Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B.

R1520 - ROC2
Figure 1. Conjugation pathways for ubiquitin and ubiquitin-like modifiers (UBLs). Most modifiers mature by proteolytic processing from inactive precursors (a; amino acid).Arrowheads point to the cleavage sites. Ubiquitin is expressed either as polyubiquitin or as a fusion with ribosomal proteins. Conjugationrequires activating (E1) and conjugating (E2) enzymes that form thiolesters (S) with the modifiers. Modification of cullins by RUBinvolves SCF(SKP1/cullin-1/F-box protein) /CBC(cullin-2/elongin B/elonginC) -like E3 enzymes that are also involved in ubiquitination.In contrast to ubiquitin, the UBLs do not seem to form multi-UBL chains. UCRP(ISG15) resembles two ubiquitin moieties linked headto-tail. Whether HUB1 functions as a modifier is currently unclear.APG12 and URM1 are distinct from the other modifiers because they are unrelated in sequence to ubiquitin. Data contributed by S.Jentsch, see references above.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ROC2 (C-term) antibody
Figure 1. Conjugation pathways for ubiquitin and ubiquitin-like modifiers (UBLs). Most modifiers mature by proteolytic processing from inactive precursors (a; amino acid). Arrowheads point to the cleavage sites. Ubiquitin is expressed either as polyubiquitin or as a fusion with ribosomal proteins. Conjugation requires activating (E1) and conjugating (E2) enzymes that form thiolesters (S) with the modifiers. Modification of cullins by RUB involves SCF(SKP1/cullin-1/F-box protein) /CBC(cullin-2/elongin B/elonginC) -like E3 enzymes that are also involved in ubiquitination. In contrast to ubiquitin, the UBLs do not seem to form multi-UBL chains. UCRP(ISG15) resembles two ubiquitin moieties linked headto-tail. Whether HUB1 functions as a modifier is currently unclear. APG12 and URM1 are distinct from the other modifiers because they are unrelated in sequence to ubiquitin. Data contributed by S.Jentsch, see references above. Rabbit Serum Ce, Hu, Ms, Ze E, IP, WB
0.1 ml / €515.00
  OriGene Technologies GmbH

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Available Filters

Product Type
  1. Primary Antibody (1)
Clonality
  1. Polyclonal (1)
Property
  1. C-term (1)
Reactivity
  1. C. elegans (Ce) (1)
  2. Human (Hu) (1)
  3. Mouse (Ms) (1)
  4. Zebrafish (Ze) (1)
Applications
  1. Enzyme Immunoassay (E) (1)
  2. Immunoprecipitation (IP) (1)
  3. Western blot / Immunoblot (WB) (1)
Presentation
  1. Serum (1)
Host
  1. Rabbit (1)
Images
  1. 1 image (1)
Manufacturer
  1. OriGene Technologies (1)
Service
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  • Germany
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