RTEL1 antibody
Principal name
RTEL1 antibody
Alternative names for RTEL1 antibody
C20orf41, KIAA1088, NHL, Novel helicase-like, Regulator of telomere elongation helicase 1
Gene ID
51750 (RTEL1)
Ncbi ID
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)
Background of RTEL1 antibody
RTEL1 (Regulator of Telomere Length 1) is a nuclear iron-sulfur cluster containing ATP-dependent D helicase essential to genomic stability. RTEL1 contains 1 helicase ATP-binding domain and it belongs to helicase family, RAD3/XPD subfamily. Origilly discovered in mouse, RTEL1 is a domint factor controlling the regulation of telomeric length and genomic integrity, and recent evidence suggest that RTEL1 is preferentially recruited to, or exerts greater activity at genome's G-rich regions. In D double-strand breaks (DSBs) repair, RTEL1 disrupts D-loops in vitro and promotes synthesis-dependent strand annealing (SDSA) in vivo to direct D DSBs into non-crossover outcomes during mitotic repair. RTEL1 activity is also essential to meiotic recombition regulation as shown in C elegans. RTEL1's multiple roles in genomic stability maintence and recombition regulation suggests it as a tumor suppressor. Indeed, RTEL1 mutation represents a risk factor for glioma and it is overexpressed in gastrointestil cancers. Human RTEL1 deficiency caused Hoyeraal-Hreidarsson syndrome (HHS), a severe variant of Dyskeratosis Congenita (DC), characterized by early onset bone marrow failure, immunodeficiency and developmental defects.
- Quick-Filters:
- Highly Validated (1)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA336935 | RTEL1 antibody |
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| Rabbit Polyclonal RTEL1 Antibody | |||||||
![Western Blot: RTEL1 Antibody [TA336935] - WB analysis of RTEL1 in HeLa cell lysate.](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/OriGene/NBP2-22360-1-W.jpg) |
Rabbit | Purified | Hu, Ms | C, ICC/IF, IP, P, WB |
0.1 ml /
€415.00
|
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| OriGene Technologies, Inc. | |||||||
 +3 additional images |
Highly validated antibody! |
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| TA317260 | RTEL1 (N-term) antibody |
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| RTEL1 Rabbit Polyclonal (N-Terminus) Antibody | |||||||
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Rabbit | IgG | Aff - Purified | Hu, Ms | E, P, WB |
50 µg /
€425.00
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| OriGene Technologies, Inc. | |||||||
CRISPR
| Catalog No. | Species | Donor Vector | |
|---|---|---|---|
| KN214507 | RTEL1 - human gene knockout kit via CRISPR |
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Human | GFP-Puro |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN214507BN | RTEL1 - human gene knockout kit via CRISPR |
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|
Human | mBFP-Neo |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN214507LP | RTEL1 - human gene knockout kit via CRISPR |
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Human | Luciferase-Puro |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN214507RB | RTEL1 - human gene knockout kit via CRISPR |
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Human | RFP-BSD |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
Lysates
| Catalog No. | ||
|---|---|---|
| LY409841 | RTEL1 overexpression lysate |
|
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0.1 mg /
€495.00
|
|
| OriGene Technologies, Inc. |
Human Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RC214507L2V | Lenti ORF particles, RTEL1 (mGFP-tagged)-Human regulator of telomere elongation helicase 1 (RTEL1), transcript variant 1, 200 uL, >10^7 TU/mL |
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200 µl /
€2,540.00
|
|
| OriGene Technologies, Inc. | ||
| RC221988L2V | Lenti ORF particles, RTEL1 (mGFP-tagged) - Human regulator of telomere elongation helicase 1 (RTEL1), transcript variant 2, 200 uL, >10^7 TU/mL |
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200 µl /
€2,660.00
|
|
| OriGene Technologies, Inc. | ||
| RC214507L1V | Lenti ORF particles, RTEL1 (Myc-DDK-tagged)-Human regulator of telomere elongation helicase 1 (RTEL1), transcript variant 1, 200 uL, >10^7 TU/mL |
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200 µl /
€2,290.00
|
|
| OriGene Technologies, Inc. | ||
| RC221988L1V | Lenti ORF particles, RTEL1 (Myc-DDK tagged) - Human regulator of telomere elongation helicase 1 (RTEL1), transcript variant 2 , 200 uL, >10^7 TU/mL |
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|
200 µl /
€2,410.00
|
|
| OriGene Technologies, Inc. | ||
