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SCN1B antibody

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Principal name

SCN1B antibody

Alternative names for SCN1B antibody

Sodium channel subunit beta-1

SwissProt ID

P53788 (Rabit), P97952 (Mouse), Q00954 (Rat), Q07699 (Human), Q17QN4 (Bovin), Q4PPC4 (Canfa)

Gene ID

6324 (SCN1B), 29686 (Scn1b), 20266

Ncbi ID

9606, NP_001028, NP_001028.1, NM_199037, NM_001037, NP_058984.1, NP_035452.1, NM_011322, NM_017288

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Enzyme Immunoassay (E)

Background of SCN1B antibody

Voltage-gated sodium channels (v) are essential for the generation of action potentials and for cell excitability. To date, nine v α subunits have been cloned and med v1.1-v1.9.2,3 Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β-subunits (v β-subunit). The v β-subunit gene family consists of four members: β1 (SCN1B), β2 (SCN2B), β3 (SCN3B), and β4 (SCN4B) having type I topology, containing an extracellular amino-terminus, a single transmembrane segment, and an intracellular carboxyl-terminus.They modulate channel gating, assembly, and cell surface expression in heterologous cell systems. vβ-subunits are cell adhesion molecules of the Ig superfamily, which interact with extracellular matrix, transmembrane sigling, and cell adhesion molecules. In the adult central nervous system and heart, sodium channels are associate with β1- β4 subunits, whereas in adult skeletal muscle they are associate only with the β1 subunit. This association appears to be a late event in sodium channel biosynthesis.

General readings

Selmer,K.K., (2008) Acta Neurol. Scand. 117 (4), 289-292

ARP35028_P050 - SCN1B
Human HeLa; WB Suggested Anti-SCN1B Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Hela cell lysate; SCN1B antibody - middle region (ARP35028_P050) in Human HeLa cells using Western Blot
PAB13688 - SCN1B
Western blot analysis of cell and tissue lysates with SCN1B polyclonal antibody ( Cat # PAB13688 ).Lane 1 : Rat brain tissue.Lane 2 : Rat testicular tissue.Lane 3 : MCF-7.Lane 4 : HeLa.Lane 5 : MM231.Lane 6 : HT-1080.
AP23388PU-N - SCN1B
Western blot with SCN1B Polyclonal Antibody
AP53815PU-N - SCN1B
Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human brain tissue stained with SCN1B Antibody (N-term) Cat.-No AP53815PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SCN1B Antibody (N-Term) for immunohistochemistry. Clinical relevance has not been evaluated.
AP53815PU-N - SCN1B
Western blot analysis of SCN1B Antibody (N-Term) Cat.-No AP53815PU-N in Mouse Neuro-2a cell line lysates (35ug/lane). This demonstrates the SCN1B antibody detected the SCN1B protein (arrow).
AP53815PU-N - SCN1B
Flow Cytometric analysis of Hela cells using SCN1B Antibody (N-Term) Cat.-No AP53815PU-N (Right histogram) compared to a negative control cell (Left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
TA329046 - SCN1B
Western blot analysis of rat brain (lanes 1 and 4), mouse brain (lanes 2 and 5) and rat skeletal muscle (lanes 3 and 6): 1-3. Anti-NaVß1 (extracellular) antibody , (1:400). 4-6. Anti-NaVß1 (extracellular) antibody, preincubated with the control peptide antigen.
TA329046 - SCN1B
Expression of NaVß1 in rat DRG Immunohistochemical staining of adult rat dorsal root ganglion (DRG) using Anti- NaVß1 (extracellular) antibody followed by goat anti-rabbit-AlexaFluor-594 secondary antibody. A. Navß1 labeling (red) appears in the cell bodies of the DRG neurons. B. Nuclear staining using DAPI as the counterstain (blue). C. Merged image of A and B.
TA329046 - SCN1B
Expression of NaVß1 in differentiated rat PC12 cells Immunocytochemical staining of live and intact differentiated rat PC12 cells. PC12 differentiation was induced by mNGF 2.5S (>95%). A, C. Merge of NaVß1 staining using Anti-NaVß1 (extracellular) antibody, (1:50), (red) with live cell imaging. B, D. Merge of NaVß1 staining (1:50), (red) with nuclear staining using DAPI as the counterstain.
TA338513 - SCN1B
WB Suggested Anti-SCN1B Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Hela cell lysate
TA338796 - SCN1B
WB Suggested Anti-Scn1b Antibody; Titration: 1.0 ug/ml; Positive Control: Rat Thymus

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SCN1B (N-term) antibody
Western blot with SCN1B Polyclonal Antibody Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €390.00
  OriGene Technologies GmbH

SCN1B (N-term) antibody
Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human brain tissue stained with SCN1B Antibody (N-term) Cat.-No AP53815PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SCN1B Antibody (N-Term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu, Ms F, P, WB
0.4 ml / €415.00
  OriGene Technologies GmbH
+2 additional images

2 Item(s)

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Product Type
  1. Primary Antibody (2)
Clonality
  1. Polyclonal (2)
Target
  1. SCN1B (2)
Property
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Reactivity
  1. Human (Hu) (2)
  2. Mouse (Ms) (2)
  3. Rat (Rt) (1)
Applications
  1. Western blot / Immunoblot (WB) (2)
  2. Flow cytometry (F) (1)
  3. Paraffin Sections (P) (1)
Host
  1. Rabbit (2)
Images
  1. 1 image (2)
  2. 3+ images (1)
Images: Applications
  1. Western blot / Immunoblot (WB) (2)
  2. Flow cytometry (F) (1)
  3. Paraffin Sections (P) (1)
Manufacturer
  1. OriGene Technologies (2)
Service
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