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SCN2B antibody

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Principal name

SCN2B antibody

Alternative names for SCN2B antibody

UNQ326/PRO386, Gm183, Sodium channel subunit beta-2

SwissProt ID

O60939 (Human), P54900 (Rat), Q56A07 (Mouse), Q864L3 (Canfa)

Gene ID

6327 (SCN2B), 25349 (Scn2b), 72821

Ncbi ID

9606, 10116, NP_004579.1, NP_004579, NP_001014761.1, NP_037009.1, BC092225, NM_001014761, NM_012877, NM_004588

Available reactivities

Hu (Human), Rt (Rat), Can (Canine), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of SCN2B antibody

Voltage-gated sodium channels (V) are essential for the generation of action potentials and for cell excitability. To date, nine V α subunits have been cloned and med V1.1-V1.9.2,3 Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β-subunits (Vβ-subunit). The V β-subunit gene family consists of four members: β1 (SCN1B), β2 (SCN2B), β3 (SCN3B), and β4 (SCN4B) having type I topology, containing an extracellular amino-terminus, a single transmembrane segment, and an intracellular carboxyl-terminus.They modulate channel gating, assembly, and cell surface expression in heterologous cell systems. V β-subunits are cell adhesion molecules of the Ig superfamily, which interact with extracellular matrix, transmembrane sigling, and cell adhesion molecules. In the adult central nervous system and heart, sodium channels are associate with β1- β4 subunits, whereas in adult skeletal muscle they are associate only with the β1 subunit. This association appears to be a late event in sodium channel biosynthesis. Expression of β2-subunits increases in sensory neurons following nerve injury. β2 deficient mice develop less mechanical allodynia in compare to wild type mice, suggesting a role for β2 subunit in pain sensation.

H00006327-M01 - SCN2B
Detection limit for recombinant GST tagged SCN2B is approximately 0.03ng/ml as a capture antibody.
AP08900PU-N - SCN2B
Brain, cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
CPA2049-100ul - SCN2B
Western blot analysis of SCN2B expression in HEK293T (A); Raw264.7 (B); rat liver (C) whole cell lysates.
TP760275 - SCN2B
73-379 - SCN2B
Immunoblot against crude membranes from adult rat brain (RBM) and wild-type (WT) and Navbeta2 knockout (KO) mouse brains probed with N395/68 (left) and N52A/42 (right) TC supe. Mouse brains courtesy of Lori Isom (University of Michigan).
73-379 - SCN2B
Adult rat hippocampus immunohistochemistry
TA314509 - SCN2B
Western blot analysis of extracts from 293 cells, using SCN2B antibody.The lane on the right is treated with the synthesized peptide.
TA329032 - SCN2B
Western blot analysis of rat brain membranes under reducing (lanes 1 and 2) or non-reducing (lanes 3 and 4) conditions:* 1,3. Anti-Navβ2 antibody , (1:200). 2,4. Anti-Navβ2 antibody, preincubated with the control peptide antigen. * Navβ2 is disulfide-linked to the α subunit of voltage-gated Na+ channels (Schmidt, J.W., and Catterall, W.A. (1986) Cell 46, 437.)
TA329032 - SCN2B
Expression of Navβ2 in mouse cerebellum. Immunohistochemical staining of mouse cerebellum using Anti-Navβ2 antibody . A. Navβ2 channel (red) appears in Purkinje cells (vertical arrows) and in small cells in the molecular layer (horizontal arrows, Mol). B. Staining of Purkinje nerve cells with mouse anti-calcium binding protein (CBD28k, green) demonstrates the restriction of Navβ2 to cell bodies. C, Confocal merge of Navβ2 and CBD28k.
TA329032 - SCN2B
Expression of Navβ2 in rat cerebellum. Immunohistochemical staining of rat cerebellum using Anti-Navβ2 antibody . A. Navβ2 channel (red) appears in Purkinje cells (horizontal arrows) and is distributed diffusely in the molecular layer (Mol). B. Staining of Purkinje nerve cells with mouse anti-calcium binding protein (CBD28k, green) demonstrates the restriction of Navβ2 to cell bodies. C. Confocal merge of Navβ2 and CBD28k.

9 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SCN2B antibody
  Rabbit polyclonal anti-SCN2B antibody  
Western blot analysis of extracts from 293 cells, using SCN2B antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

SCN2B antibody
  Rabbit polyclonal Anti-Nabeta2  
Western blot analysis of rat brain membranes under reducing (lanes 1 and 2) or non-reducing (lanes 3 and 4) conditions:* 1,3. Anti-Navβ2 antibody , (1:200). 2,4. Anti-Navβ2 antibody, preincubated with the control peptide antigen. * Navβ2 is disulfide-linked to the α subunit of voltage-gated Na+ channels (Schmidt, J.W., and Catterall, W.A. (1986) Cell 46, 437.) Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €585.00
  OriGene Technologies, Inc.
+2 additional images

SCN2B antibody
Immunoblot against crude membranes from adult rat brain (RBM) and wild-type (WT) and Navbeta2 knockout (KO) mouse brains probed with N395/68 (left) and N52A/42 (right) TC supe. Mouse brains courtesy of Lori Isom (University of Michigan). Mouse IgG1 N395/68 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €490.00
  Antibodies Incorporated
+1 additional image

NeuroMab

SCN2B (N-term) antibody
Brain, cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Rt E, P, WB
50 µg / €425.00
  OriGene Technologies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SCN2B (full length, N-term HIS tag)
  Recombinant protein of human sodium channel, voltage-gated, type II, beta (SCN2B), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug  
SCN2B Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.		 E. coli
50 µg / €205.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Scn2b (GFP-tagged) - Mouse sodium channel, voltage-gated, type II, beta (cDNA clone MGC:116602 IMAGE:6839081), 200 uL, >10^7 TU/mL
Lenti ORF particles, Scn2b (GFP-tagged) - Mouse sodium channel, voltage-gated, type II, beta (cDNA clone MGC:116602 IMAGE:6839081), 200 uL, >10^7 TU/mL  
200 µl / €840.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Scn2b (Myc-DDK-tagged) - Mouse sodium channel, voltage-gated, type II, beta (cDNA clone MGC:116602 IMAGE:6839081), 200 uL, >10^7 TU/mL
Lenti ORF particles, Scn2b (Myc-DDK-tagged) - Mouse sodium channel, voltage-gated, type II, beta (cDNA clone MGC:116602 IMAGE:6839081), 200 uL, >10^7 TU/mL  
200 µl / €740.00
  OriGene Technologies, Inc.
 

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Scn2b (GFP-tagged ORF) - Rat sodium channel, voltage-gated, type II, beta (Scn2b), 200 uL, >10^7 TU/mL
Lenti ORF particles, Scn2b (GFP-tagged ORF) - Rat sodium channel, voltage-gated, type II, beta (Scn2b), 200 uL, >10^7 TU/mL  
200 µl / €930.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Scn2b (Myc-DDK-tagged ORF) - Rat sodium channel, voltage-gated, type II, beta (Scn2b), 200 uL, >10^7 TU/mL
Lenti ORF particles, Scn2b (Myc-DDK-tagged ORF) - Rat sodium channel, voltage-gated, type II, beta (Scn2b), 200 uL, >10^7 TU/mL  
200 µl / €830.00
  OriGene Technologies, Inc.
 

9 Item(s)

per page

Available Filters

Product Type
  1. Mouse Lenti ORF Particle (2)
  2. Primary Antibody (4)
  3. Protein | Growth Factor (1)
  4. Rat Lenti ORF Particle (2)
Clonality
  1. Polyclonal (3)
  2. Monoclonal (1)
Target
  1. SCN2B (5)
Property
  1. N-term (1)
Reactivity
  1. Human (Hu) (3)
  2. Mouse (Ms) (3)
  3. Rat (Rt) (3)
Applications
  1. Western blot / Immunoblot (WB) (4)
  2. Enzyme Immunoassay (E) (2)
  3. Frozen sections (C) (1)
  4. Immunocytochemistry/​Immunofluorescence (ICC/IF) (1)
  5. Paraffin Sections (P) (1)
Presentation
  1. Purified (2)
  2. Aff - Purified (1)
  3. Supernatant (1)
Host
  1. Rabbit (3)
  2. Mouse (1)
Images
  1. 1 image (5)
  2. 3+ images (1)
Images: Applications
  1. Western blot / Immunoblot (WB) (3)
  2. Frozen sections (C) (1)
  3. IHC (1)
  4. Paraffin Sections (P) (1)
Species (Protein)
  1. Human (1)
Source
  1. E. coli (1)
Manufacturer
  1. OriGene Technologies (8)
  2. Antibodies Incorporated (1)
Service
  • OriGene Technologies GmbH
  • Schillerstraße 5
  • D-32052 Herford
  • Germany
  • phone: +49-5221-34606-0
  • free call: 0800-227 47 46 (Germany only)
  • fax: +49-5221-34606-11
  • email: info-de@origene.com
  • orders: ordering-de@origene.com
 
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