SCN4A antibody
Principal name
SCN4A antibody
Alternative names for SCN4A antibody
SkM1, Sodium channel protein type 4 subunit alpha, Sodium channel protein type IV subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.4, Sodium channel protein skeletal muscle subunit alpha
Ncbi ID
Available reactivities
Available hosts
Available applications
Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB)
Background of SCN4A antibody
Voltage-gated sodium channels (v) are essential for the generation of action potentials and for cell excitability. v channels are activated in response to depolarization and selectively allow flow of + ions. The v channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive and TTX-resistant channels. Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. To date, nine v α subunits have been cloned and med v1.1-v1.9.4-5 Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1 subunit. The isoform v1.4, is primarily expressed in skeletal muscle. Different missense mutations in the gene for the v1.4 are correlated with several muscular diseases such as, Paramyotonia congenital (PMC), PMC without cold paralysis, potassium-aggravating myotonia, and hyperkalemic periodic paralysis.
General readings
Gershome C, Lin E, Kashihara H, Hove-Madsen L, Tibbits GF. Colocalization of voltage-gated Na+ channels with the Na+/Ca2+ exchanger in rabbit cardiomyocytes during development. Am J Physiol Heart Circ Physiol. 2011 Jan;300(1)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA329043 | SCN4A antibody |
||||||
| Rabbit polyclonal Anti-NaV1.4 | |||||||
 |
Rabbit | Purified | Hu, Rt | WB |
0.2 ml /
€585.00
|
||
| OriGene Technologies, Inc. | |||||||
| AP55279SU-N | SCN4A antibody |
||||||
 |
Rabbit | Serum | Hu | C, E, WB |
0.2 ml /
€430.00
|
||
| OriGene Technologies GmbH | |||||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY424791 | SCN4A overexpression lysate |
|
|
0.1 mg /
€495.00
|
|
| OriGene Technologies, Inc. |
Human Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RC218290L1V | Lenti ORF particles, SCN4A (Myc-DDK tagged) - Human sodium channel, voltage-gated, type IV, alpha subunit (SCN4A), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€2,420.00
|
|
| OriGene Technologies, Inc. | ||