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SCN8A antibody

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Principal name

SCN8A antibody

Alternative names for SCN8A antibody

MED, Nav1.6, Sodium channel protein type 8 subunit alpha, Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6

SwissProt ID

O88420 (Rat), Q9UQD0 (Human), Q9WTU3 (Mouse)

Gene ID

6334 (SCN8A), 29710 (Scn8a)

Ncbi ID

9606, NP_055006, NP_001171455.1, NP_062139, NP_062139.2, NM_014191

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Rt (Rat), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP)

Background of SCN8A antibody

Voltage-gated sodium channels (V) are essential for the generation of action potentials and for cell excitability. V channels are activated in response to depolarization and selectively allow flow of + ions. To date, nine V α subunits have been cloned and med V1.1-V1.9.4-5 The V channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (V1.1, V1.2, V1.3, V1.4, V1.6 and V1.7) and TTX-resistant (V1.5, V1.8 and V1.9). Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. Expression of the α subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1 subunit. V1.6 is highly expressed in adult brain and localized at high density in nodes of Ranvier and axon initial segments and at lower density in dendrites and cell bodies of some neurons. V1.6 channels are also expressed at high levels in cerebellar Purkinje neurons.

H00006334-M04 - SCN8A
Immunofluorescence of monoclonal antibody to SCN8A on NIH/3T3 cell. [antibody concentration 10 ug/ml]
H00006334-M04 - SCN8A
SCN8A monoclonal antibody (M04), clone 4G7 Western Blot analysis of SCN8A expression in NIH/3T3 ( Cat # L018V1 ).
ARP35227_P050 - SCN8A
Human NCI-H226; Host: Rabbit . Target Name: SCN8A . Sample Tissue: NCI-H226 . Antibody Dilution: 1.0ug/ml. SCN8A is supported by BioGPS gene expression data to be expressed in NCIH226.; SCN8A antibody - middle region (ARP35227_P050) in Human NCI-H226 cells using Western Blot
ARP35227_P050 - SCN8A
Human Muscle; WB Suggested Anti-SCN8A Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Human Muscle; SCN8A antibody - middle region (ARP35227_P050) in Human Muscle cells using Western Blot
CPA2051-100ul - SCN8A
Western blot analysis of Nav1.6 expression in MCF7 (A); Raw264.7 (B); H9C2 (C) whole cell lysates.
75-026 - SCN8A
Cerebellar granule cells, 16 days in culture, obtained from wild-type (WT) and Nav1.6-null “Null” mice. K87A/10=green. DAPI=blue. Scale bar = 20 μm. Images courtesy of Drs. L. M. Sharkey and M. H. Meisler, University of Michigan School of Medicine.
75-026 - SCN8A
Adult rat optic nerve immunofluorescence staining K87A/10=red Rabbit anti-Caspr=green Image courtesy of Dr. Matthew Rasband (Baylor College of Medicine).
73-026 - SCN8A
Cerebellar granule cells, 16 days in culture, obtained from wild-type (WT) and Nav1.6-null “Null” mice. K87A/10=green. DAPI=blue. Scale bar = 20 μm. Images courtesy of Drs. L. M. Sharkey and M. H. Meisler, University of Michigan School of Medicine.
73-026 - SCN8A
Adult rat optic nerve immunofluorescence staining K87A/10=red Rabbit anti-Caspr=green Image courtesy of Dr. Matthew Rasband (Baylor College of Medicine).
TA309441 - SCN8A
IHC analysis of Nav1.6 using TA309441, tested on mouse brain hippocampus. Neurons with a good granular positivity in the cytoplasm and positivity showing axons.
TA329034 - SCN8A
Western blot analysis of rat brain membrane: 1. Anti-Nav1.6 antibody , (1:200). 2. Anti-Nav1.6 antibody, preincubated with the control peptide antigen.
TA329034 - SCN8A
Expression of Nav1.6 in mouse hippocampus. Immunohistochemical staining of mouse hippocampus using Anti-Nav1.6 antibody . A. Nav1.6 (green) is robustly expressed in the CA1 pyramidal layer (white arrows). B. Staining with mouse anti-parvalbumin (red), a marker of interneurons. C. merged image of panels A and B reveals that Nav1.6 appears in some interneurons (arrow) but is not restricted to interneurons. DAPI is used as the counterstain.
TA329034 - SCN8A
Expression of Nav1.6 in rat DRG primary culture. Immunocytochemical staining of paraformaldehyde-fixed and permeabilized DRG primary culture. A. Staining using Anti-Nav1.6 antibody , (1:200) followed by goat anti-rabbit-AlexaFluor-555 secondary antibody. B. Nuclear staining using the cell-permeable dye Hoechst 33342. C. Merged image of panels A and B.
TA338572 - SCN8A
WB Suggested Anti-SCN8A Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Muscle
TA338572 - SCN8A
Host: Rabbit; Target Name: SCN8A; Sample Tissue: NCI-H226; Antibody Dilution: 1.0 ug/ml SCN8A is supported by BioGPS gene expression data to be expressed in NCIH226

6 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SCN8A antibody
  Mouse Monoclonal anti-SCN8A Antibody  
IHC analysis of Nav1.6 using TA309441, tested on mouse brain hippocampus. Neurons with a good granular positivity in the cytoplasm and positivity showing axons. Mouse IgG1 S87A-10 Purified Hu, Ms, Rt C, IP
0.1 mg / €410.00
  OriGene Technologies, Inc.

SCN8A antibody
  Rabbit polyclonal Anti-NaV1.6  
Western blot analysis of rat brain membrane: 1. Anti-Nav1.6 antibody , (1:200). 2. Anti-Nav1.6 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €585.00
  OriGene Technologies, Inc.
+2 additional images

SCN8A antibody
Cerebellar granule cells, 16 days in culture, obtained from wild-type (WT) and Nav1.6-null “Null” mice. K87A/10=green. DAPI=blue. Scale bar = 20 μm. Images courtesy of Drs. L. M. Sharkey and M. H. Meisler, University of Michigan School of Medicine. Mouse IgG1 K87A/10 Supernatant Hu, Ms, Rt C, ICC/IF, IP
5 ml / €490.00
  Antibodies Incorporated
+1 additional image

NeuroMab

SCN8A antibody
Cerebellar granule cells, 16 days in culture, obtained from wild-type (WT) and Nav1.6-null “Null” mice. K87A/10=green. DAPI=blue. Scale bar = 20 μm. Images courtesy of Drs. L. M. Sharkey and M. H. Meisler, University of Michigan School of Medicine. Mouse IgG1 K87A/10 Purified Hu, Ms, Rt C, ICC/IF, IP
0.1 ml / €570.00
  Antibodies Incorporated
+1 additional image

NeuroMab

SCN8A antibody
SCN8A Rabbit Serum Hu C, E, WB
0.2 ml / €430.00
  OriGene Technologies GmbH

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SCN8A (Myc-DDK tagged) - Human sodium channel, voltage gated, type VIII, alpha subunit (SCN8A), transcript variant 1, 200 uL, >10^7 TU/mL
Lenti ORF particles, SCN8A (Myc-DDK tagged) - Human sodium channel, voltage gated, type VIII, alpha subunit (SCN8A), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,420.00
  OriGene Technologies, Inc.
 

6 Item(s)

per page

Available Filters

Product Type
  1. Human Lenti ORF Particle (1)
  2. Primary Antibody (5)
Clonality
  1. Monoclonal (3)
  2. Polyclonal (2)
Target
  1. SCN8A (5)
Reactivity
  1. Human (Hu) (5)
  2. Mouse (Ms) (4)
  3. Rat (Rt) (4)
Applications
  1. Frozen sections (C) (4)
  2. Immunoprecipitation (IP) (3)
  3. Immunocytochemistry/​Immunofluorescence (ICC/IF) (2)
  4. Western blot / Immunoblot (WB) (2)
  5. Enzyme Immunoassay (E) (1)
Presentation
  1. Purified (3)
  2. Serum (1)
  3. Supernatant (1)
Host
  1. Mouse (3)
  2. Rabbit (2)
Images
  1. 1 image (4)
  2. 3+ images (1)
Images: Applications
  1. Immunocytochemistry/​Immunofluorescence (ICC/IF) (2)
  2. IHC (2)
  3. Immunofluorescence (IF) (1)
  4. Western blot / Immunoblot (WB) (1)
Manufacturer
  1. OriGene Technologies (4)
  2. Antibodies Incorporated (2)
Service
  • OriGene Technologies GmbH
  • Schillerstraße 5
  • D-32052 Herford
  • Germany
  • phone: +49-5221-34606-0
  • free call: 0800-227 47 46 (Germany only)
  • fax: +49-5221-34606-11
  • email: info-de@origene.com
  • orders: ordering-de@origene.com
 
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