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SENP6 antibody

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Principal name

SENP6 antibody

Alternative names for SENP6 antibody

Sentrin-specific protease 6, KIAA0797, SSP1, SUSP1, Sentrin/SUMO-specific protease SENP6, SUMO-1-specific protease 1

SwissProt ID

Q6P7W0 (Mouse), Q9GZR1 (Human)

Gene ID

26054 (SENP6), 215351 (Senp6)

Ncbi ID

9606, NP_001093879, NP_001093879.1, NP_666115.2, NM_146003, NM_015571, NM_001100409

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Eq (Equine), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of SENP6 antibody

SENP6 is a UBL-specific protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. It does not seem to be involved in the processing of full-length SUMO proteins to their mature forms. SENP6 deconjugates SUMO1 from RXRA, leading to transcriptiol activation. It may act preferentially on substrates containing 3 or more SUMO2 or SUMO3 moieties.Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-termil glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]).[supplied by OMIM].

General readings

Choi SJ, Chung SS, Rho EJ, Lee HW, Lee MH, Choi HS, Seol JH, Baek SH, Bang OS, Chung CH.
Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1.
J Biol Chem. 2006 Oct 13;281(41):30669-77. Epub 2006 Aug 15.
PMID: 16912044

H00026054-M01 - SENP6
Immunoperoxidase of monoclonal antibody to SENP6 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml]
H00026054-M01 - SENP6
SENP6 monoclonal antibody (M01), clone 4B7 Western Blot analysis of SENP6 expression in IMR-32 ( Cat # L008V1 ).
H00026054-M01 - SENP6
Detection limit for recombinant GST tagged SENP6 is approximately 0.03ng/ml as a capture antibody.
AP06460PU-N - SENP6
Immunohistochemistry (IHC) analyzes of SENP6 antibody (Cat.-No.: AP06460PU-N) in paraffin-embedded human lung carcinoma tissue.
PAB1849 - SENP6
Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with SENP6 polyclonal antibody ( Cat # PAB1849 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
PAB1849 - SENP6
Western blot analysis of SENP6 polyclonal antibody ( Cat # PAB1849 ) in HL-60 cell lysate. SENP6 ( arrow ) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
PAB7602 - SENP6
SENP6 polyclonal antibody ( Cat # PAB7602 ) ( 0.5 µg/ml ) staining of HeLa cell nuclear lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence.
AP11242PU-N - SENP6
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
AP11242PU-N - SENP6
Western blot analysis of SENP6 polyclonal antibody (Cat. #AP11242PU-N) in HL60 cell lysate. SENP6 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
ARP50600_P050 - SENP6
Rat; . Sample Type: 1.Rat Testis cells (200ug) . Primary Dilution: 1:1000. Secondary Antibody: alkaline phosphatase-conjugated anti-rabbit. Secondary Dilution: 1:1000. Image Submitted by: Andreia Carvalho. IBMC-OBF, Portugal . See Customer Feedback tab for detailed information.. .; SENP6 antibody - C-terminal region (ARP50600_P050) in Rat cells using Western Blot
ARP50600_P050 - SENP6
Human 721_B; WB Suggested Anti-SENP6 Antibody Titration: 0.2-1 ug/ml. Positive Control: 721_B cell lysate. SENP6 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells.; SENP6 antibody - C-terminal region (ARP50600_P050) in Human 721_B cells using Western Blot
C0369-1 - SENP6
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using SENP6 Antibody. The picture on the right is treated with the synthesized peptide.
TA303331 - SENP6
TA303331 (0.5µg/ml) staining of HeLa cell nuclear lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
TA315306 - SENP6
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using SENP6 antibody.The picture on the right is treated with the synthesized peptide.
TA339719 - SENP6
Sample Type: 1.Rat Testis cells (200ug); Primary Dilution: 1: 1000; Secondary Antibody: alkaline phosphatase-conjugated anti-rabbit; Secondary Dilution: 1: 1000; Image Submitted by: Andreia Carvalho; IBMC-OBF, Portugal See Customer Feedback tab for detail
TA339719 - SENP6
WB Suggested Anti-SENP6 Antibody Titration: 0.2-1 ug/ml; Positive Control: 721_B cell lysate SENP6 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells

9 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SENP6 antibody
  Goat Polyclonal Antibody against SENP6  
TA303331 (0.5µg/ml) staining of HeLa cell nuclear lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €360.00
  OriGene Technologies, Inc.

SENP6 antibody
  Rabbit polyclonal anti-SENP6 antibody  
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using SENP6 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P
0.1 ml / €335.00
  OriGene Technologies, Inc.

SENP6 antibody
  Rabbit Polyclonal Anti-SENP6 Antibody  
SENP6 Rabbit IgG Purified Hu E, P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

SENP6 antibody
Immunohistochemistry (IHC) analyzes of SENP6 antibody (Cat.-No.: AP06460PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu P
0.1 mg / €370.00
  OriGene Technologies GmbH

SENP6 (C-term) antibody
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €415.00
  OriGene Technologies GmbH
+1 additional image

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SENP6 (mGFP-tagged) - Human SUMO1/sentrin specific peptidase 6 (SENP6), transcript variant 1, 200 uL, >10^7 TU/mL
Lenti ORF particles, SENP6 (mGFP-tagged) - Human SUMO1/sentrin specific peptidase 6 (SENP6), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,360.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, SENP6 (Myc-DDK tagged) - Human SUMO1/sentrin specific peptidase 6 (SENP6), transcript variant 1 , 200 uL, >10^7 TU/mL
Lenti ORF particles, SENP6 (Myc-DDK tagged) - Human SUMO1/sentrin specific peptidase 6 (SENP6), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €2,120.00
  OriGene Technologies, Inc.
 

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Senp6 (GFP-tagged) - Mouse SUMO/sentrin specific peptidase 6 (Senp6), 200 uL, >10^7 TU/mL
Lenti ORF particles, Senp6 (GFP-tagged) - Mouse SUMO/sentrin specific peptidase 6 (Senp6), 200 uL, >10^7 TU/mL  
200 µl / €2,070.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Senp6 (Myc-DDK-tagged) - Mouse SUMO/sentrin specific peptidase 6 (Senp6), 200 uL, >10^7 TU/mL
Lenti ORF particles, Senp6 (Myc-DDK-tagged) - Mouse SUMO/sentrin specific peptidase 6 (Senp6), 200 uL, >10^7 TU/mL  
200 µl / €1,870.00
  OriGene Technologies, Inc.
 

9 Item(s)

per page

Available Filters

Product Type
  1. Human Lenti ORF Particle (2)
  2. Mouse Lenti ORF Particle (2)
  3. Primary Antibody (5)
Clonality
  1. Polyclonal (5)
Target
  1. SENP6 (5)
Property
  1. C-term (1)
Reactivity
  1. Human (Hu) (5)
  2. Mouse (Ms) (1)
  3. Rat (Rt) (1)
Applications
  1. Paraffin Sections (P) (4)
  2. Enzyme Immunoassay (E) (3)
  3. Western blot / Immunoblot (WB) (3)
Presentation
  1. Purified (3)
  2. Aff - Purified (2)
Host
  1. Rabbit (4)
  2. Goat (1)
Images
  1. 1 image (4)
Images: Applications
  1. Paraffin Sections (P) (2)
  2. Western blot / Immunoblot (WB) (2)
  3. IHC (1)
Manufacturer
  1. OriGene Technologies (9)
Service
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