SHOC2 antibody
Principal name
SHOC2 antibody
Alternative names for SHOC2 antibody
SHOC-2, Protein soc-2 homolog, Protein sur-8 homolog, SOC2, SUR8, KIAA0862, Leucine-rich repeat protein SHOC-2
Ncbi ID
9606, NP_031399.2, NM_007373, NP_031399, NP_001161977.1, BC026364, NM_001168505, NM_019658, NM_001013155
Available reactivities
Available hosts
Available applications
Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)
Background of SHOC2 antibody
SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA306795 | SHOC2 antibody |
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| Rabbit Polyclonal SHOC2 Antibody | |||||||
 |
Rabbit | IgG | Aff - Purified | Hu, Ms, Rt | E, P, WB |
0.1 mg /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
 +1 additional image |
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| AP55056SU-N | SHOC2 antibody |
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 |
Rabbit | Serum | Hu | C, E, WB |
0.2 ml /
€430.00
|
||
| OriGene Technologies GmbH | |||||||
Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP308396 | SHOC2 |
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| Recombinant protein of human soc-2 suppressor of clear homolog (C. elegans) (SHOC2) | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY416022 | SHOC2 overexpression lysate |
|
|
0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. |
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR208396L2V | Lenti ORF particles, Shoc2 (GFP-tagged) - Mouse soc-2 (suppressor of clear) homolog (C. elegans) (cDNA clone MGC:31051 IMAGE:4014650), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,240.00
|
|
| OriGene Technologies, Inc. | ||
| MR209116L2V | Lenti ORF particles, Shoc2 (GFP-tagged) - Mouse soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2), transcript variant 2, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,240.00
|
|
| OriGene Technologies, Inc. | ||
| MR208396L1V | Lenti ORF particles, Shoc2 (Myc-DDK-tagged) - Mouse soc-2 (suppressor of clear) homolog (C. elegans) (cDNA clone MGC:31051 IMAGE:4014650), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,110.00
|
|
| OriGene Technologies, Inc. | ||
| MR209116L1V | Lenti ORF particles, Shoc2 (Myc-DDK-tagged) - Mouse soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2), transcript variant 2, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,110.00
|
|
| OriGene Technologies, Inc. | ||
Rat Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RR205028L2V | Lenti ORF particles, Shoc2 (GFP-tagged ORF) - Rat soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,310.00
|
|
| OriGene Technologies, Inc. | ||
| RR205028L1V | Lenti ORF particles, Shoc2 (Myc-DDK-tagged ORF) - Rat soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,170.00
|
|
| OriGene Technologies, Inc. | ||