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SIGLEC11 antibody

Principal name

SIGLEC11 antibody

Alternative names for SIGLEC11 antibody

SIGLEC-11, UNQ9222/PRO28718, Sialic acid-binding Ig-like lectin 11, Sialic acid-binding lectin 11

SwissProt ID

Q96RL6 (Human)

Gene ID

114132 (SIGLEC11)

Ncbi ID

9606, NP_001128635.1, NP_443116.2, NM_052884, NM_001135163, NP_443116

Available reactivities

Hu (Human)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of SIGLEC11 antibody

Siglecs are sialic acid-binding lectins of the immunoglobulin superfamily that are mainly expressed in cells of the hematopoietic system. Siglec11 is unlike other siglecs in that it binds specifically to a2-8-linked sialic acids and is not found in peripheral blood leukocytes but instead on macrophages of various tissues. Siglec11 is highly homologous to Siglec10 over their extracellular domain but not over their cytoplasmic domain, suggesting that Siglec11 arose through gene duplication followed by a recombination event involving another ancestral siglec gene. Following treatment of Siglec11-transfected cells with pervanadate, Siglec11 becomes tyrosine-phosphorylated and strongly associates with SHP-1 and SHP-2. At least five isoforms of Siglec11 are known to exist.

Formalin-fixed and paraffin-embedded human cancer tissue reacted with SIGLEC11 polyclonal antibody ( Cat # PAB3646 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.

PAB3646

Western blot analysis of Siglec11 in HepG2 cell lysate with Siglec11 antibody at 1 ug/ml.

TA306773

Immunohistochemistry of Siglec11 in human liver tissue with Siglec11 antibody at 5 ug/ml.

TA306773

Immunofluorescence of SIGLEC11 in human liver tissue with SIGLEC11 antibody at 20 ug/mL.

TA306773

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (SIGLEC11 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

TA351668

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using (SIGLEC11 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

TA351668

Primary Antibodies

Catalog No.	Host	Iso.	Pres.	React.	Applications
TA306773	SIGLEC11 antibody
	Rabbit Polyclonal Siglec11 Antibody
	Rabbit	IgG	Aff - Purified	Hu	E, P, WB	0.1 mg / €415.00
						OriGene Technologies, Inc.
+2 additional images
TA351668	SIGLEC11 antibody
	Rabbit Polyclonal Anti-SIGLEC11 Antibody
	Rabbit	IgG	Purified	Hu	E, P	0.1 ml / €335.00
						OriGene Technologies, Inc.
+1 additional image

Lysates

Catalog No.
LY403267	SIGLEC11 overexpression lysate
		0.1 mg / €495.00
		OriGene Technologies, Inc.
LY427568	SIGLEC11 overexpression lysate
		0.1 mg / €315.00
		OriGene Technologies, Inc.
LY432355	SIGLEC11 overexpression lysate
		0.1 mg / €495.00
		OriGene Technologies, Inc.

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