SKA2 antibody
Principal name
SKA2 antibody
Alternative names for SKA2 antibody
FAM33A, Spindle and kinetochore-associated protein 2
Ncbi ID
NP_872426.1, NP_872426, NP_079653.1, NM_025377, NM_001009624, NM_182620
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C)
Background of SKA2 antibody
Upon entry into mitosis, the cell’s microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing. SKA2 has also been shown to interact with glucocorticoid receptors and to be involved in glucocorticoid signaling and cell proliferation.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA306844 | SKA2 antibody |
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| Rabbit Polyclonal SKA2 Antibody | |||||||
 |
Rabbit | IgG | Aff - Purified | Hu, Ms | E, WB |
0.1 mg /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
| AP23903PU-N | SKA2 (N-term) antibody |
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 |
Rabbit | Purified | Hu, Ms | E, P, WB |
50 µg /
€425.00
|
||
| OriGene Technologies GmbH | |||||||
 +1 additional image |
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| AP53923PU-N | SKA2 (N-term) antibody |
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 |
Rabbit | Ig | Aff - Purified | Hu | P, WB |
0.4 ml /
€415.00
|
|
| OriGene Technologies GmbH | |||||||
| +1 additional image |
|||||||
| AP55296SU-N | SKA2 antibody |
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 |
Rabbit | Serum | Hu | C, E, WB |
0.2 ml /
€430.00
|
||
| OriGene Technologies GmbH | |||||||
Rat Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RR215228L2V | Lenti ORF particles, Ska2 (GFP-tagged ORF) - Rat family with sequence similarity 33, member A (Fam33a), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€930.00
|
|
| OriGene Technologies, Inc. | ||
| RR215228L1V | Lenti ORF particles, Ska2 (Myc-DDK-tagged ORF) - Rat family with sequence similarity 33, member A (Fam33a), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€830.00
|
|
| OriGene Technologies, Inc. | ||
