SPAM1 antibody
Principal name
SPAM1 antibody
Alternative names for SPAM1 antibody
Sperm adhesion molecule 1, Hyaluronidase PH-20, Hyal-PH20, PH20, HYAL3
Ncbi ID
9606, NP_003108, NP_001167515.1, NP_001073344.1, NM_009241, NM_053967, NM_153189, NM_001174044, NM_001174045, NM_001174046
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB)
Background of SPAM1 antibody
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctiol protein is a hyaluronidase that ebles sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell sigling, and a receptor that is involved in sperm-zo pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA327282 | SPAM1 antibody |
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| Rabbit anti-SPAM1 Polyclonal Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu |
0.1 mg /
€335.00
|
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| OriGene Technologies, Inc. | |||||||
 +1 additional image |
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Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP305378 | SPAM1 (transcript variant 1) |
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| Recombinant protein of human sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (SPAM1), transcript variant 1 | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR219759L2V | Lenti ORF particles, Spam1 (GFP-tagged) - Mouse sperm adhesion molecule 1 (Spam1), transcript variant 2, 200 uL, >10^7 TU/mL |
|
 |
200 µl /
€1,210.00
|
|
| OriGene Technologies, Inc. | ||
| MR219759L1V | Lenti ORF particles, Spam1 (Myc-DDK-tagged) - Mouse sperm adhesion molecule 1 (Spam1), transcript variant 2, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,080.00
|
|
| OriGene Technologies, Inc. | ||
Rat Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RR211737L2V | Lenti ORF particles, Spam1 (GFP-tagged ORF) - Rat sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (Spam1), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,200.00
|
|
| OriGene Technologies, Inc. | ||
| RR211737L1V | Lenti ORF particles, Spam1 (Myc-DDK-tagged ORF) - Rat sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) (Spam1), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,080.00
|
|
| OriGene Technologies, Inc. | ||
