STRAP antibody
Principal name
STRAP antibody
Alternative names for STRAP antibody
MAWD, UNRIP, Serine-threonine kinase receptor-associated protein, MAP activator with WD repeats, UNR-interacting protein, WD-40 repeat protein PT-WD
Ncbi ID
9606, NP_009109, NP_009109.3, NP_035629.2, NM_011499, NM_001011969, NM_007178
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), Paraffin Sections (P)
Background of STRAP antibody
Unrip is part of the SMN complex that plays a role in snRNP assembly in the cytoplasm and pre mRNA splicing in the nucleus. Unrip interacts directly with Gemin 6 and Gemin 7 in the SMN complex. It is associated with the complex in the cytoplasm but not in the nucleus and thus is thought to play a role in it's subcellular localisation.
It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.
General readings
Seong,H.A., (2005) J. Biol. Chem. 280 (52), 42897-42908
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| AP08285PU-N | STRAP (230-280) antibody |
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 |
Rabbit | IgG | Purified | Bov, Can, Chk, Eq, Hu, Mky, Ms, Xen, Ze | P, WB |
50 µg /
€425.00
|
|
| OriGene Technologies GmbH | |||||||
| AP17770PU-N | STRAP (C-term) antibody |
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 |
Rabbit | Hu | WB |
0.4 ml /
€415.00
|
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| OriGene Technologies GmbH | |||||||
Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP309149 | STRAP |
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| Recombinant protein of human serine/threonine kinase receptor associated protein (STRAP) | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||