TGFB1 antibody
Principal name
TGFB1 antibody
Alternative names for TGFB1 antibody
TGFB, Transforming growth factor beta-1, TGF-beta-1
SwissProt ID
O19011 (Horse), P01137 (Human), P04202 (Mouse), P07200 (Pig), P09531 (Chick), P17246 (Rat), P18341 (Bovin), Q9Z1Y6 (Cavpo)
Ncbi ID
NP_000651.3, NP_999180.1, NP_035707, 9606, 10090, NP_000651, NP_067589, NP_067589.1, NP_035707.1, AAH01180.1, NP_004603.1, NM_000660, NM_011577, NM_021578
Available reactivities
Available hosts
Available applications
Frozen Sections (C), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Functional assay (FN), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Neutralisation (NEUT)
Background of TGFB1 antibody
Transforming growth factor (TGF), a Â?factorÂ? that promoted the transformation of cultured fibroblasts into a tumor-like phenotype, was subsequently found to be more of a tumor suppressor than tumor promoter and to be a mixture of two proteins, TGF-. and TGF-.. These molecules are members of a superfamily that includes TGF-.1 through 5, bone morphogenic proteins, activins and inhibins. It plays a critical role in cellular growth, development, differentiation, proliferation, extracellular matrix (ECM) synthesis and degradation, control of mesenchymal-epithelial interactions during embryogenesis, immune modulation, apoptosis, cell cycle progression, angiogenesis, adhesion and migration and leukocyte chemotaxis.
Originally, TGF-.1 was separated from platelets and later found that TGF-.1 can be expressed in many organizations. Human TGF-.1 is a 25kDa, disulfide-linked, non-glycosylated homodimer. Biological activity of TGF-.1 is regulated by a number of receptors, including receptor I (53-65KD), receptor II (83-110KD), receptor III (250-310KD), receptor-IV (60KD) and receptor V (400KD).
TGF-.1 is the key mediator in the pathophysiology of tissue repair and human fibrogenesis: balance between production and degradation of type I collagen, and fibrosis and scarring in organ and tissue. TGF-.1 exhibits important immunoregulatory features of partially adverse character: TGF-.1 inhibits B and T cell proliferation, differentiation and antibody production as well as maturation and activation of macrophages. TGF-.1 is synthesized, with only a few exceptions, by virtually all cells, and TGF receptors are expressed by all cells. TGF-. affects nearly every physiological process in some way; its systemic and cell-specific activities are too complicated to review here. There are, however, three fundamental activities: TGF-.1 modulates cell proliferation, generally as a suppressor; TGF-.1 enhances the deposition of extracellular matrix through promotion of synthesis and inhibition of degradation; TGF-.1 is immunosuppressive through a variety of mechanisms. The specific action of TGF-. on a particular cell depends on the exact circumstances of that cellÂ?s environment.
General readings
Kingsley, D.M. (1994) Genes Dev. 8:133.
Javelaud, D. and A. Mauviel (2004) Int. J. Biochem. Cell Biol. 36:1161.
Chang, H. et al. (2002) Endocr. Rev. 23:787.
Kondaiah, P. et al. (1988) J. Biol. Chem. 263:18313.
Clark, D.A. and R. Coker (1998) Int. J. Biochem. Cell Biol. 30:293.
Qian, S.W. et al. (1990) Nucleic Acids Res. 18:3059.
Derynack, R. et al. (1986) J. Biol. Chem. 261:4377.
Dubois, C.M. et al. (1995) J. Biol. Chem. 270:10618.
Manning, A.M. et al. (1995) Gene 155:307.
Brunner, A.M. et al. (1989) J. Biol. Chem. 264:13660.
Mittl, P.R.E. et al. (1996) Protein Sci. 5:1261.
Gray, A.M. and A.J. Mason (1990) Science 247:1328.
Oklu, R. and R. Hesketh (2000) Biochem. J. 352:601.
Saharinen, J. et al. (1996) EMBO J. 15:245.
Mangasser-Stephan, K. and A.M. Gressner (1999) Cell Tissue Res. 297:363.
Koli, K. et al. (2001) J. Cell Sci. 114:2869.
Yang, L. et al. (2000) Wound Rep. Reg. 8:538.
Pedrozo, H.A. et al. (1999) Endocrinology 140:5806.
Yu, Q. and I. Stamenkovic (2000) Genes Dev. 14:163.
Maeda, S. et al. (2001) J. Bone Miner. Res. 16:1281.
Munger, J.S. et al. (1999) Cell 96:319.
Derynck, R. et al. (1985) Nature 316:701.
Derynck, R. and X-H. Feng (1997) Biochim. Biophys. Acta 1333:F105.
Ten Dijke, P. et al. (1996) Curr. Opin. Cell. Biol. 8:139.
Chai, Y. et al. (2003) Crit. Rev. Oral Biol. Med. 14:78.
de Caestecker, M. et al. (2004) Cytokine Growth Factor Rev. 15:1.







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- Quick-Filters:
- Cited (3)
- Highly Validated (2)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| AP06350PU-N | TGFB1 antibody |
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Rabbit | Aff - Purified | Hu, Ms, Rt | ICC/IF, P, WB |
0.1 mg /
€370.00
|
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| OriGene Technologies GmbH | |||||||
+2 additional images |
Published recently! |
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| DM1047 | TGFB1 antibody |
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Mouse | IgG1 | TB21 | Azide Free | Hu, Sh | C, E, FN, P, WB |
0.5 mg /
€520.00
|
| OriGene Technologies GmbH | |||||||
Published recently! |
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| TA506585 | TGFB1 antibody |
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| TGFB1 mouse monoclonal antibody, clone OTI1E12 (formerly 1E12) | |||||||
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Mouse | IgG2a | OTI1E12 | Purified | Hu | F, ICC/IF, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+3 additional images |
Highly validated antibody! |
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| AP54230PU-N | TGFB1 (N-term) antibody |
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Rabbit | Ig | Aff - Purified | Hu, Ms | ICC/IF, P, WB |
0.4 ml /
€415.00
|
|
| OriGene Technologies GmbH | |||||||
+3 additional images |
Highly validated antibody! |
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| TA310081 | TGFB1 antibody |
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| Rabbit anti-TGFB1 polyclonal antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | P, WB |
0.1 ml /
€220.00
|
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA313319 | TGFB1 antibody |
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| Rabbit polyclonal anti-TGF Beta1 antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, P, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA319281 | TGFB1 (286-293) antibody |
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| Rabbit polyclonal TGF beta 1 antibody | |||||||
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Rabbit | IgG | Aff - Purified | Hu | E, WB |
0.1 mg /
€515.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA323601 | TGFB1 antibody |
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| Anti-TGFB1 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, P |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA347822 | TGFB1 antibody |
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| Rabbit Polyclonal Anti-TGF beta1 Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA506583 | TGFB1 antibody |
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| TGFB1 mouse monoclonal antibody, clone OTI3B6 (formerly 3B6) | |||||||
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Mouse | IgG2a | OTI3B6 | Purified | Hu | ICC/IF, WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| TA506584 | TGFB1 antibody |
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| TGFB1 mouse monoclonal antibody, clone OTI2B5 (formerly 2B5) | |||||||
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Mouse | IgG2a | OTI2B5 | Purified | Hu | WB |
0.1 ml /
€360.00
|
| OriGene Technologies, Inc. | |||||||
| AM01369PU-N | TGFB1 antibody |
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Mouse | IgG2a | Azide Free | Hu | E, P, WB |
0.5 mg /
€220.00
|
|
| OriGene Technologies GmbH | |||||||
+1 additional image |
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| AM06127SU-N | TGFB1 antibody |
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Mouse | IgG2a | GE 4.90 | Ascites | Hu | E, WB |
0.1 ml /
€270.00
|
| OriGene Technologies GmbH | |||||||
| AM39040PU-N | TGFB1 antibody |
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Mouse | IgG1 | TB21 | Aff - Purified | Hu | C, E, F, NEUT, P, WB |
1.0 ml /
€560.00
|
| OriGene Technologies GmbH | |||||||
+1 additional image |
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| AP07828PU-N | TGFB1 (286-293) antibody |
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Rabbit | Aff - Purified | Hu | E, ICC/IF, P, WB |
50 µg /
€425.00
|
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| OriGene Technologies GmbH | |||||||
+1 additional image |
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| DM1044 | TGFB1 antibody |
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Mouse | IgG1 | 2C5 | Azide Free | Hu | E, WB |
0.5 mg /
€520.00
|
| OriGene Technologies GmbH | |||||||
| DM1045 | TGFB1 antibody |
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Mouse | IgG1 | 2C6 | Azide Free | Hu | C, E, FN, WB |
0.5 mg /
€520.00
|
| OriGene Technologies GmbH | |||||||
| DM1046 | TGFB1 antibody |
||||||
![]() |
Mouse | IgG1 | 2E6 | Azide Free | Hu | E, WB |
0.5 mg /
€520.00
|
| OriGene Technologies GmbH | |||||||
| DM1050 | TGFB1 antibody |
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Mouse | IgG1 | 8C4 | Azide Free | Hu | C, E, FN |
0.5 mg /
€520.00
|
| OriGene Technologies GmbH | |||||||
CRISPR
| Catalog No. | Species | Donor Vector | |
|---|---|---|---|
| KN200973 | TGFB1 - human gene knockout kit via CRISPR |
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Human | GFP-Puro |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||






















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