Theophylline antibody
Principal name
Theophylline antibody
Available hosts
Available applications
Enzyme Immunoassay (E), Radioimmunoassay (R), Immunocytochemistry/Immunofluorescence (ICC/IF)
Background of Theophylline antibody
Theophylline is a colorless crystalline alkaloid, derived from tea leaves or made synthetically, used in medicine especially as a bronchial dilator.
Theophylline, the most common Methylxanthine, causes mild to moderate bronchodilation. Some recent evidence suggests that Theophyline may also have a mild anti-inflammatory component. Sustained release Theophylline's principle use is as adjuvant therapy and it is particularly useful in controlling nocturnal symptoms. Theophylline inhibits the TGF-beta regulated conversion of pulmonary fibroblasts into myofibroblasts via cyclic adenosine monophosphate (cAMP)-PKA pathway, and it suppresses COL1 mRNA which codes for the protein collagen. Theophylline also directly activates histone deacetylase (HDAC),
an enzyme that mediates inflammatory responses, and it decreases the levels of interleukin-4 (IL-4) and cyclic guanosine monophosphate (cGMP).