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TIMP3 antibody

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Principal name

TIMP3 antibody

Alternative names for TIMP3 antibody

Protein MIG-5, TIMP-3, Metalloproteinase inhibitor 3, Tissue inhibitor of metalloproteinases 3

SwissProt ID

O73746 (Xenla), O97590 (Rabit), P26652 (Chick), P35625 (Human), P39876 (Mouse), P48032 (Rat), P79121 (Bovin), Q9TUL9 (Horse)

Gene ID

7078 (TIMP3), 373596 (timp3), 21859 (Timp3)

Ncbi ID

9606, 8355, NP_000353, NP_000353.1, 10116, AAH14277, NM_000362, NP_035725.1, NM_011595

Available reactivities

Frog, Hu (Human), Rb (Rabbit), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of TIMP3 antibody

The tissue inhibitors of metalloproteinases (TIMPs) are naturally occurring proteins that specifically inhibit matrix metalloproteinases and regulate extracellular matrix turnover and tissue remodeling by forming tightly bound inhibitory complexes with the MMPs. Thus, TIMPs maintain the balance between matrix destruction and formation. An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP proteins share several structural features including six loops held in place by six disulfide bonds arranged in three knotlike structures. The N terminal region is necessary for inhibitory activity. The N terminus of each TIMP contains a consensus sequence (VIRAK) and each TIMP is translated with a 29 amino acid leader sequence that is cleaved to produce the mature protein. The C terminal regions are divergent and enhance the inhibition selectivity and binding efficiency. Although the TIMP proteins share high homology, following secretion they are localized extracellularly either in soluble form (TIMP1, TIMP2, and TIMP4) or bound to extracellular matrix components (TIMP3).

AP15823PU-S - TIMP3
Human placenta stained with Anti-TIMP-3 antibody
PAB11828 - TIMP3
Immunohistochemical staining of TIMP3 on formalin fixed, paraffin embedded human placenta with TIMP3 polyclonal antibody.
PAB8014 - TIMP3
Western blot analysis of rat kidney tissue lysate. Using TIMP3 polyclonal antibody ( Cat # PAB8014 ) .
AP20507PU-N - TIMP3
Western blot (WB) analysis of TIMP-3 antibody (Cat.-No. AP20507PU-N) in extracts from HUVEC cells.
C0349-1 - TIMP3
Western blot analysis of extracts from HuvEc cells, using TIMP3 Antibody. The lane on the right is treated with the synthesized peptide.
ARP59183_P050 - TIMP3
Human MCF-7; WB Suggested Anti-TIMP3 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: MCF7 cell lysate; TIMP3 antibody - N-terminal region (ARP59183_P050) in Human MCF-7 cells using Western Blot
ARP59182_P050 - TIMP3
Human MCF-7; WB Suggested Anti-TIMP3 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: MCF7 cell lysate; TIMP3 antibody - middle region (ARP59182_P050) in Human MCF-7 cells using Western Blot
AP23357PU-N - TIMP3
Western blot analysis of rat kidney tissue lysis using TIMP3 antibody
AP54257PU-N - TIMP3
Formalin-fixed and paraffin-embedded human breast carcinoma reacted with TIMP3 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
AP54257PU-N - TIMP3
Western blot analysis of TIMP3 Antibody (Center) (AP54257PU-N) in HepG2 cell line lysates (35 µg/lane). TIMP3 (arrow) was detected using the purified Pab.
AP54257PU-N - TIMP3
TIMP3 Antibody (Center) (AP54257PU-N) flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
AP32837PU-T - TIMP3
Formalin-Fixed, Paraffin-Embedded Human placenta stained with TIMP3 Antibody Cat.-No AP32837PU.
CPA2166-100ul - TIMP3
Western blot analysis of TIMP3 expression in HepG2 (A); HeLa (B); NIH3T3 (C) whole cell lysates.
CEK1345 - Human TIMP3 ELISA Kit
Representative Standard Curve
TA314625 - TIMP3
Western blot analysis of extracts from HUVEC cells, using TIMP3 antibody.The lane on the right is treated with the synthesized peptide.
TA321115 - TIMP3
Predicted band size: 24 kDa . Positive control: Huvec cell lysate. Recommended dilution: 1/200-1000. (Gel: 12%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/250 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 seconds)
TA321115 - TIMP3
Predicted cell location: Cytoplasm. Positive control: Human thyroid cancer tissue. Recommended dilution: 1/15-50 The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using TIMP3 antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification:x200)
TA347482 - TIMP3
Western blot analysis on HuvEc cell lysate using TIMP3 Antibody

12 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TIMP3 (175-211) antibody
Formalin-Fixed, Paraffin-Embedded Human placenta stained with TIMP3 Antibody Cat.-No AP32837PU. Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Rt F, ICC/IF, IP, P, WB
0.1 mg / €430.00
  OriGene Technologies GmbH
 

OriGene recommends this product for Immunohistochemistry.

TIMP3 (175-211) antibody
Formalin-Fixed, Paraffin-Embedded Human placenta stained with TIMP3 Antibody Cat.-No AP32837PU. Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Rt F, ICC/IF, IP, P, WB
20 µg / €240.00
  OriGene Technologies GmbH
 

OriGene recommends this product for Immunohistochemistry.

TIMP3 antibody
  Rabbit polyclonal anti-TIMP3 antibody  
Western blot analysis of extracts from HUVEC cells, using TIMP3 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

TIMP3 antibody
  Anti-TIMP3 Rabbit Polyclonal Antibody  
Predicted band size: 24 kDa . Positive control: Huvec cell lysate. Recommended dilution: 1/200-1000. (Gel: 12%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/250 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.
+1 additional image

TIMP3 antibody
  Rabbit Polyclonal Anti-TIMP3 Antibody  
Western blot analysis on HuvEc cell lysate using TIMP3 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €335.00
  OriGene Technologies, Inc.

TIMP3 antibody
Western blot (WB) analysis of TIMP-3 antibody (Cat.-No. AP20507PU-N) in extracts from HUVEC cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €370.00
  OriGene Technologies GmbH

TIMP3 (C-term) antibody
Western blot analysis of rat kidney tissue lysis using TIMP3 antibody Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €390.00
  OriGene Technologies GmbH

TIMP3 (Center) antibody
Formalin-fixed and paraffin-embedded human breast carcinoma reacted with TIMP3 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €415.00
  OriGene Technologies GmbH
+2 additional images

ELISA Kits

Catalog No.    

Human TIMP-3 ELISA Kit
Human TIMP-3 ELISA Kit  
1 kit / €535.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

TIMP3 overexpression lysate
TIMP3 overexpression lysate  
0.1 mg / €295.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Timp3 (GFP-tagged) - Mouse tissue inhibitor of metalloproteinase 3 (Timp3), 200 uL, >10^7 TU/mL
Lenti ORF particles, Timp3 (GFP-tagged) - Mouse tissue inhibitor of metalloproteinase 3 (Timp3), 200 uL, >10^7 TU/mL  
200 µl / €930.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Timp3 (Myc-DDK-tagged) - Mouse tissue inhibitor of metalloproteinase 3 (Timp3), 200 uL, >10^7 TU/mL
Lenti ORF particles, Timp3 (Myc-DDK-tagged) - Mouse tissue inhibitor of metalloproteinase 3 (Timp3), 200 uL, >10^7 TU/mL  
200 µl / €830.00
  OriGene Technologies, Inc.
 

12 Item(s)

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Available Filters

Product Type
  1. ELISA Kit (1)
  2. Lysate (1)
  3. Mouse Lenti ORF Particle (2)
  4. Primary Antibody (8)
Clonality
  1. Polyclonal (8)
Target
  1. TIMP3 (8)
Property
  1. 175-211 (2)
  2. C-term (1)
  3. Center (1)
Reactivity
  1. Human (Hu) (9)
  2. Mouse (Ms) (7)
  3. Rat (Rt) (7)
  4. Bovine (Bov) (2)
  5. Canine (Can) (2)
  6. Equine (Eq) (2)
Applications
  1. Western blot / Immunoblot (WB) (8)
  2. Paraffin Sections (P) (4)
  3. Flow cytometry (F) (3)
  4. Enzyme Immunoassay (E) (2)
  5. Immunocytochemistry/​Immunofluorescence (ICC/IF) (2)
  6. Immunoprecipitation (IP) (2)
Presentation
  1. Purified (5)
  2. Aff - Purified (3)
Host
  1. Rabbit (8)
Images
  1. 1 image (8)
  2. 3+ images (1)
Images: Applications
  1. Western blot / Immunoblot (WB) (6)
  2. Paraffin Sections (P) (3)
  3. Flow cytometry (F) (1)
  4. IHC (1)
Manufacturer
  1. OriGene Technologies (12)
Service
  • OriGene Technologies GmbH
  • Schillerstraße 5
  • D-32052 Herford
  • Germany
  • phone: +49-5221-34606-0
  • free call: 0800-227 47 46 (Germany only)
  • fax: +49-5221-34606-11
  • email: info-de@origene.com
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