TOP2B antibody

Background of TOP2B antibody

TOP2B is a D topoisomerase, an enzyme that controls and alters the topologic states of D during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsiol stress that occurs during D transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex D which allows the strands to pass through one another, thus altering the topology of D. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. This gene encodes a D topoisomerase, an enzyme that controls and alters the topologic states of D during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsiol stress that occurs during D transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex D which allows the strands to pass through one another, thus altering the topology of D. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Altertive splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additiol publications.