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TREM2 antibody

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Principal name

TREM2 antibody

Alternative names for TREM2 antibody

TREM-2, Trem2a, Trem2b, Trem2c, Triggering receptor expressed on myeloid cells 2, Triggering receptor expressed on monocytes 2

SwissProt ID

Q99NH8 (Mouse), Q9NZC2 (Human)

Gene ID

54209 (TREM2), 83433 (Trem2)

Ncbi ID

9606, NP_061838.1, 10090, NP_112544.1, NM_018965, NP_061838, NM_031254

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Eq (Equine)

Available hosts

Goat, Mouse, Rat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP)

Background of TREM2 antibody

TREM-2 is a 26 kDa transmembrane glycoprotein that consists of a single extracellular immunoglobulin-like domain, a transmembrane region with a charged lysine residue and a short cytoplasmic tail. It associates with DNAX-activation protein 12 (DAP12) for signaling and function. TREM-2 is expressed on immature monocyte-derived dendritic cells. After activation by microbial products or tumor necrosis factor (TNF) and TNF-related proteins, dendritic cells downregulate the expression of TREM-2. TREM-2 is also expressed by osteoclasts and microglia, where it is involved in bone modeling and brain function, respectively. Another role of TREM-2 might be promoting the removal of apoptotic cells, organic matrix and macromolecules by microglia. Defects in TREM-2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). TREM-2, like TREM-1, can be cleaved on the membrane to release a soluble form of TREM-2 (sTREM-2). Elevated levels of sTREM-2 in CSF of multiple sclerosis patients have been detected. This elevated level may inhibit the anti-inflammatory function of the membrane-bound receptor suggesting sTREM-2 to be a possible target for future therapies.

General readings

Takahashi K, Prinz M, Stagi M, Chechneva O, Neumann H. TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis. PLoS Med. 2007 Apr;4(4):e124. PMID: 17425404

AM09045PU-N - TREM2
Western blot analysis: Cell lysates of HeLa, MCF7, LNCaP and mouse brain (30 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human TREM2 (1/500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
MAB2056 - TREM2
Cell lysates of HeLa ( lane 1 ), MCF-7 ( lane 2 ), LNCaP ( lane 3 ) and mouse brain ( lane 4 ) ( 30 µg ) were resolved by SDS-PAGE and probed with TREM2 monoclonal antibody, clone 2B5 ( Cat # MAB2056 ) ( 1:500 ). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
AP08790PU-N - TREM2
Spleen, macrophages: Formalin-Fixed Paraffin-Embedded (FFPE)
AP23686PU-N - TREM2
Sstaining of Mouse Liver lysate using Anti-TREM2 Antibody Cat.-No AP23686PU-N at 0.3 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
ARP49413_P050 - TREM2
Human Muscle; WB Suggested Anti-TREM2 Antibody Titration: 0.2-1 ug/ml. Positive Control: Human Muscle; TREM2 antibody - middle region (ARP49413_P050) in Human Muscle cells using Western Blot
AR51272PU-N - TREM2
TA305737 - TREM2
TA305737 (2.5ug/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
TA331072 - TREM2
WB Suggested Anti-TREM2 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human Muscle

14 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

TREM2 antibody
AP23686PU-N (1µg/ml) staining of Mouse Spinal Cord lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Ms E, WB
0.1 mg / €380.00
  OriGene Technologies GmbH
 

OriGene recommends this product for Western blotting.

TREM2 (C-term) antibody
  Goat Anti-TREM2 Antibody  
TA305737 (2.5ug/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Hu P
0.1 mg / €360.00
  OriGene Technologies, Inc.

TREM2 antibody
  Rabbit Polyclonal Anti-TREM2 Antibody  
TREM2 Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

TREM2 antibody
Western blot analysis: Cell lysates of HeLa, MCF7, LNCaP and mouse brain (30 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human TREM2 (1/500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG3 2B5 Purified Hu, Ms E, WB
0.1 ml / €330.00
  OriGene Technologies GmbH

TREM2 antibody
Western blot analysis: Cell lysates of HeLa, MCF7, LNCaP and mouse brain (30 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human TREM2 (1/500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG3 2B5 Purified Hu, Ms E, WB
50 µl / €220.00
  OriGene Technologies GmbH

TREM2 antibody
TREM2 Rat IgG2b 6E9 Purified Ms E, IP
0.1 mg / €390.00
  OriGene Technologies GmbH

TREM2 (C-term) antibody
Spleen, macrophages: Formalin-Fixed Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Hu E, P
50 µg / €425.00
  OriGene Technologies GmbH

TREM2b (Extracell. Dom.) antibody
TREM2b Rat IgG2 5J46 Purified Ms WB
0.1 mg / €460.00
  OriGene Technologies GmbH

CRISPR

Catalog No. Species Donor Vector  

TREM2 - human gene knockout kit via CRISPR
TREM2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TREM2 - human gene knockout kit via CRISPR
TREM2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

TREM2 - human gene knockout kit via CRISPR
TREM2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

TREM2 - human gene knockout kit via CRISPR
TREM2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Trem2 (GFP-tagged) - Mouse triggering receptor expressed on myeloid cells 2 (Trem2), 200 uL, >10^7 TU/mL
Lenti ORF particles, Trem2 (GFP-tagged) - Mouse triggering receptor expressed on myeloid cells 2 (Trem2), 200 uL, >10^7 TU/mL  
200 µl / €930.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, Trem2 (Myc-DDK-tagged) - Mouse triggering receptor expressed on myeloid cells 2 (Trem2), 200 uL, >10^7 TU/mL
Lenti ORF particles, Trem2 (Myc-DDK-tagged) - Mouse triggering receptor expressed on myeloid cells 2 (Trem2), 200 uL, >10^7 TU/mL  
200 µl / €830.00
  OriGene Technologies, Inc.
 

14 Item(s)

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Available Filters

Product Type
  1. CRISPR (4)
  2. Mouse Lenti ORF Particle (2)
  3. Primary Antibody (8)
Clonality
  1. Monoclonal (4)
  2. Polyclonal (4)
Target
  1. TREM2 (7)
  2. TREM2b (1)
Property
  1. C-term (2)
  2. Extracell. Dom. (1)
Reactivity
  1. Mouse (Ms) (6)
  2. Human (Hu) (5)
Applications
  1. Enzyme Immunoassay (E) (6)
  2. Western blot / Immunoblot (WB) (5)
  3. Paraffin Sections (P) (2)
  4. Immunoprecipitation (IP) (1)
Presentation
  1. Purified (5)
  2. Aff - Purified (3)
Host
  1. Goat (3)
  2. Mouse (2)
  3. Rat (2)
  4. Rabbit (1)
Images
  1. 1 image (5)
Images: Applications
  1. Western blot / Immunoblot (WB) (3)
  2. IHC (1)
  3. Paraffin Sections (P) (1)
Species (CRISPR)
  1. Human (4)
Donor Vector
  1. GFP-Puro (1)
  2. Luciferase-Puro (1)
  3. RFP-BSD (1)
  4. mBFP-Neo (1)
Manufacturer
  1. OriGene Technologies (14)
Service
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