TTC8 / BBS8 antibody
Principal name
TTC8 / BBS8 antibody
Alternative names for TTC8 / BBS8 antibody
TPR repeat protein 8, Bardet-Biedl syndrome 8 protein, Tetratricopeptide repeat protein 8
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Enzyme Immunoassay (E)
Background of TTC8 / BBS8 antibody
The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.This gene encodes a protein that has been directly linked to Bardet-Biedl syndrome. The primary features of this syndrome include retil dystrophy, obesity, polydactyly, rel abnormalities and learning disabilities. Experimentation in non-human eukaryotes suggests that this gene is expressed in ciliated cells and that it is involved in the formation of cilia. Alterte transcriptiol splice variants have been characterized.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA311574 | TTC8 / BBS8 antibody |
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| Goat Anti-TTC8 Antibody | |||||||
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Goat | Aff - Purified | Bov, Can, Hu, Ms, Por | E, WB |
0.1 mg /
€360.00
|
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| OriGene Technologies, Inc. | |||||||
| AP54402PU-N | TTC8 / BBS8 (N-term) antibody |
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Rabbit | Ig | Aff - Purified | Hu | WB |
0.4 ml /
€415.00
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|
| OriGene Technologies GmbH | |||||||
Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP310638 | TTC8 / BBS8 (transcript variant 2) |
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| Recombinant protein of human tetratricopeptide repeat domain 8 (TTC8), transcript variant 2 | |||||
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Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR217657L2V | Lenti ORF particles, Ttc8 (GFP-tagged) - Mouse tetratricopeptide repeat domain 8 (Ttc8), transcript variant 1, 200 uL, >10^7 TU/mL |
|
 |
200 µl /
€1,200.00
|
|
| OriGene Technologies, Inc. | ||
| MR208262L2V | Lenti ORF particles, Ttc8 (GFP-tagged) - Mouse tetratricopeptide repeat domain 8 (Ttc8), transcript variant 2, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,210.00
|
|
| OriGene Technologies, Inc. | ||
| MR217657L1V | Lenti ORF particles, Ttc8 (Myc-DDK-tagged) - Mouse tetratricopeptide repeat domain 8 (Ttc8), transcript variant 1, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,070.00
|
|
| OriGene Technologies, Inc. | ||
| MR208262L1V | Lenti ORF particles, Ttc8 (Myc-DDK-tagged) - Mouse tetratricopeptide repeat domain 8 (Ttc8), transcript variant 2, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,080.00
|
|
| OriGene Technologies, Inc. | ||
