ZBP1 antibody
Principal name
ZBP1 antibody
Alternative names for ZBP1 antibody
C20orf183, DLM1, Z-DNA-binding protein 1
Ncbi ID
NP_110403, 9606, NP_001153889.1, NM_030776, NM_001160418, NP_001153889, NM_021394, NM_001139519, NM_001160419
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F), Paraffin Sections (P)
Background of ZBP1 antibody
Z-DNA binding protein 1 (ZBP-1) belongs to a family of proteins that contain the Zalpha domain, which binds specifically to left-handed Z-DNA and Z-RAN. Vertebrate ZBPs are induced by immunostimulation and are involved in host defense mechanisms. ZBP-1 initiates an innate immune response by binding to foreign DNA in the cytosol. ZBP-1 mediates activation of the innate immune system by facilitating DNA-mediated induction of type-1 IFN and expression of other related genes. Human ZBP-1 is most prominently expressed in lymphatic tissues. Besides its function in immunoresponse, it is up-regulated in mouse tumor stromal cells and is speculated to play a role in host defense again tumors.
Structure: 429 amino acids with predicted molecular weight of 46.3 kD.
Distribution: Cytosol.
Function: Participates in the detection of DNA from viral, bacterial, and host origin by the host's innate immune system. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production.
General readings
Rothenburg,S., et al., (2002) Nucleic Acids Res. 30 (4), 993-1000
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA306502 | ZBP1 (C-term) antibody |
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| Rabbit Polyclonal ZBP1 Antibody | |||||||
 |
Rabbit | Aff - Purified | Hu, Ms, Rt | E, P, WB |
0.1 mg /
€415.00
|
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| OriGene Technologies, Inc. | |||||||
 +2 additional images |
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| TA590283 | ZBP1 antibody |
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| Rabbit Polyclonal Z DNA binding protein Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu | E |
0.1 mg /
€409.00
|
|
| OriGene Technologies, Inc. | |||||||
Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP720577 | ZBP1 (transcript variant 1) |
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| Recombinant protein of human Z-DNA binding protein 1 (ZBP1), transcript variant 1 | |||||
 |
Human | > 95 % Preparation: . Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining. |
E. coli |
10 µg /
€299.00
|
|
| OriGene Technologies, Inc. | |||||
| TP760418 | ZBP1 (full length, N-term HIS tag, transcript variant 1) |
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| Purified recombinant protein of Human Z-DNA binding protein 1 (ZBP1), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug | |||||
 |
Human | > 80 % Preparation: . Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
E. coli |
50 µg /
€205.00
|
|
| OriGene Technologies, Inc. | |||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY403079 | ZBP1 overexpression lysate |
|
 |
0.1 mg /
€495.00
|
|
| OriGene Technologies, Inc. | ||
| LY431312 | ZBP1 overexpression lysate |
|
|
0.1 mg /
€315.00
|
|
| OriGene Technologies, Inc. |
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR206461L2V | Lenti ORF particles, Zbp1 (GFP-tagged) - Mouse Z-DNA binding protein 1 (Zbp1), transcript variant 1, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€930.00
|
|
| OriGene Technologies, Inc. | ||
| MR206461L1V | Lenti ORF particles, Zbp1 (Myc-DDK-tagged) - Mouse Z-DNA binding protein 1 (Zbp1), transcript variant 1, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€830.00
|
|
| OriGene Technologies, Inc. | ||