ZCCHC11 antibody
Principal name
ZCCHC11 antibody
Alternative names for ZCCHC11 antibody
Terminal uridylyltransferase 4, Kiaa0191, Tut4, Zinc finger CCHC domain-containing protein 11
Ncbi ID
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB)
Background of ZCCHC11 antibody
ZCCHC11 is the uridylyltransferase that acts as a suppressor of microR (miR) biogenesis by specifically mediating the termil uridylation of some miRs. ZCCHC11 catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miR precursor. Uridylated pre-let-7 miRs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintence of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency.ZCCHC11 does not bind R by itself, recruited to pre-let-7 miRs via its interaction with LIN28A and LIN28B. ZCCHC11 also catalyzes the 3' uridylation of miR-26A, a miR that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression.ZCCHC11 may also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. ZCCHC11 does not play a role in replication-dependent histone mR degradation.
General readings
1. Minoda Y, Saeki K, Aki D, Takaki H, Sanada T, Koga K, Kobayashi T, Takaesu G, Yoshimura A. A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling. Biochem Biophys Res Commun. 2006 Jun 9;344(3):1023-30. Erratum in: Biochem Biophys Res Commun. 2007 Feb 23;353(4):1121.
PMID: 16643855
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA309516 | ZCCHC11 antibody |
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| Goat Polyclonal Antibody against Terminal Uridylyltransferase 4 (mouse) | |||||||
 |
Goat | Aff - Purified | Ms, Rt | E, WB |
0.1 mg /
€360.00
|
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| OriGene Technologies, Inc. | |||||||
| AP15877PU-N | ZCCHC11 (C-term) antibody |
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 |
Goat | Aff - Purified | Bov, Can, Hu, Ms, Rt | E, P |
0.1 mg /
€380.00
|
||
| OriGene Technologies GmbH | |||||||
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR218919L2V | Lenti ORF particles, Zcchc11 (GFP-tagged) - Mouse zinc finger, CCHC domain containing 11 (Zcchc11), 200 uL, >10^7 TU/mL |
|
 |
200 µl /
€2,780.00
|
|
| OriGene Technologies, Inc. | ||
| MR218919L1V | Lenti ORF particles, Zcchc11 (Myc-DDK-tagged) - Mouse zinc finger, CCHC domain containing 11 (Zcchc11), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€2,520.00
|
|
| OriGene Technologies, Inc. | ||
