Product Description for TIE1
TIE1.
Presentation: Purified
Presentation: Purified
Properties for TIE1
| Product Category | Proteins & Growth Factors |
|---|---|
| Target Category | |
| Quantity | 0.1 mg |
| Synonyms | TIE, Tie-1, Tyrosine-protein kinase receptor Tie-1 |
| Presentation | Purified |
| Molecular weight | 250 kDa |
| Source | Insect cells |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 90 % by SDS-PAGE and visualised by silver stain. |
| Background | TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Whereas two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)], so far no ligand was found for TIE-1. |
| General Readings |
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| Storage | Store Lyophilized at -20°C. Reconstituted sTIE-1/Fc should be stored in working aliquots at -20°C to -70°C. Avoid repeated freeze-thaw cycles! Shelf life: One year from despatch. |
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