Switch to Europe/Worldwide website Switch to German website Switch to French website Switch to OriGene Technologies, Inc. (North America)
Home » Target » Carabin antibody

Carabin antibody

(reset)

Principal name

Carabin antibody

Alternative names for Carabin antibody

TBC1D10C, TBC1 domain family member 10C

SwissProt ID

Q8C9V1 (Mouse), Q8IV04 (Human)

Gene ID

374403 (TBC1D10C), 108995 (Tbc1d10c)

Ncbi ID

NP_940919.1, 9606, NP_940919, NM_198517, NP_848765.2, NM_178650

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Eq (Equine), Rb (Rabbit)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of Carabin antibody

Antigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.

AP05728PU-N - Carabin
Formalin fixed, paraffin embedded human spleen with Rabbit anti Human Carabin (AP05728PU-N) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0).
AP05728PU-N - Carabin
Western blot analysis of whole cell lysate from Daudi, Burkitt's lymphoma derived cells probed with Rabbit anti Human Carabin (AP05728PU-N) at 1(A) and 2(B) µg/ml
PAB7529 - Carabin
TBC1D10C polyclonal antibody ( Cat # PAB7529 ) ( 2 µg/ml ) staining of human spleen lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence.
PAB13276 - Carabin
Immunohistochemistry of TBC1D10C in human spleen tissue with TBC1D10C polyclonal antibody ( Cat # PAB13276 ) at 2.5 µg/ml.
PAB13276 - Carabin
Western blot analysis of TBC1D10C in Daudi cell lysate with TBC1D10C polyclonal antibody ( Cat # PAB13276 ) at ( A ) 1 and ( B ) 2 µg/ml.
PAB13277 - Carabin
Immunohistochemistry of TBC1D10C in human spleen tissue with TBC1D10C polyclonal antibody ( Cat # PAB13277 ) at 2.5 µg/ml.
PAB13277 - Carabin
Western blot analysis of TBC1D10C in human spleen tissue lysate with TBC1D10C polyclonal antibody ( Cat # PAB13277 ) at ( A ) 1 and ( B ) 2 µg/ml.
ARP55893_P050 - Carabin
Human Jurkat; WB Suggested Anti-TBC1D10C Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Jurkat cell lysate; TBC1D10C antibody - N-terminal region (ARP55893_P050) in Human Jurkat cells using Western Blot
ARP55894_P050 - Carabin
Human Thymus; WB Suggested Anti-TBC1D10C Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: Human Thymus; TBC1D10C antibody - N-terminal region (ARP55894_P050) in Human Thymus cells using Western Blot
TP309092 - Carabin
TA303203 - Carabin
TA303203 (2µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
TA306445 - Carabin
Western blot analysis of Carabin in Daudi cell lysate with Carabin antibody at (A) 1 and (B) 2 ug/ml.
TA306445 - Carabin
Immunohistochemistry of Carabin in human spleen tissue with Carabin antibody at 2.5 ug/ml.
TA306446 - Carabin
Western blot analysis of Carabin in human spleen tissue lysate with Carabin antibody at (A) 1 and (B) 2 ug/ml.
TA306446 - Carabin
Immunohistochemistry of Carabin in human spleen tissue with Carabin antibody at 2.5 ug/ml.
TA333358 - Carabin
WB Suggested Anti-TBC1D10C Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Jurkat cell lysate
TA333359 - Carabin
WB Suggested Anti-TBC1D10C Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human Thymus

6 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Carabin antibody
  Goat Polyclonal Antibody against TBC1D10C  
TA303203 (2µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Purified Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €270.00
  OriGene Technologies, Inc.

Carabin (C-term) antibody
  Rabbit Polyclonal Carabin Antibody  
Western blot analysis of Carabin in Daudi cell lysate with Carabin antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €415.00
  OriGene Technologies, Inc.
+1 additional image

Carabin (N-term) antibody
  Rabbit Polyclonal Carabin Antibody  
Western blot analysis of Carabin in human spleen tissue lysate with Carabin antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €415.00
  OriGene Technologies, Inc.
+1 additional image

Carabin (N-term) antibody
Formalin fixed, paraffin embedded human spleen with Rabbit anti Human Carabin (AP05728PU-N) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0). Rabbit IgG Purified Hu, Ms P, WB
0.1 mg / €410.00
  OriGene Technologies GmbH
+1 additional image

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Carabin
  Recombinant protein of human TBC1 domain family, member 10C (TBC1D10C)  
Carabin Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.		 HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.
 

Lysates

Catalog No.    

TBC1D10C overexpression lysate
TBC1D10C overexpression lysate  
0.1 mg / €295.00
  OriGene Technologies, Inc.

6 Item(s)

per page

Available Filters

Product Type
  1. Lysate (1)
  2. Primary Antibody (4)
  3. Protein | Growth Factor (1)
Clonality
  1. Polyclonal (4)
Target
  1. Carabin (5)
Property
  1. C-term (1)
  2. N-term (2)
Reactivity
  1. Human (Hu) (4)
  2. Mouse (Ms) (4)
  3. Canine (Can) (1)
  4. Porcine (Por) (1)
  5. Rat (Rt) (1)
Applications
  1. Western blot / Immunoblot (WB) (4)
  2. Enzyme Immunoassay (E) (3)
  3. Paraffin Sections (P) (3)
Presentation
  1. Aff - Purified (2)
  2. Purified (2)
Host
  1. Rabbit (3)
  2. Goat (1)
Images
  1. 1 image (5)
Images: Applications
  1. Western blot / Immunoblot (WB) (4)
  2. IHC (2)
  3. Paraffin Sections (P) (1)
Species (Protein)
  1. Human (1)
Source
  1. HEK293 cells (1)
Manufacturer
  1. OriGene Technologies (6)
Service
  • OriGene Technologies GmbH
  • Schillerstraße 5
  • D-32052 Herford
  • Germany
  • phone: +49-5221-34606-0
  • free call: 0800-227 47 46 (Germany only)
  • fax: +49-5221-34606-11
  • email: info-de@origene.com
  • orders: ordering-de@origene.com
 
© Copyright 1998 - 2018 OriGene Technologies GmbH
  • LinkedIn