Caspase-1 antibody
Principal name
Caspase-1 antibody
Alternative names for Caspase-1 antibody
CASP-1, CASP1, IL1BC, IL1BCE, ICE, p45, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme
Ncbi ID
NP_001214.1, 9606, 7108, NP_033937, NP_001214, NP_033937.2, NP_150635.1, NP_150634.1, NM_033292, NM_033293, NM_033294, NM_001223, NP_150636, NP_150635, NP_150634
Available reactivities
Available hosts
Available applications
Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Flow Cytometry (F), Frozen Sections (C)
Background of Caspase-1 antibody
Caspase-1, or interleukin-1ß converting enzyme (ICE/ICEa), is a class I cysteine protease, which also includes caspases -4, -5, -11, and -12. Caspase-1 cleaves inflammatory cytokines such as pro-IL-1ß and interferon-? inducing factor (IL-18) into their mature forms . Like other caspases, caspase-1 is proteolytically activated from a proenzyme to produce a tetramer of its two active subunits, p20 and p10. Caspase-1 has a large amino-termil pro-domain that contains a caspase recruitment domain (CARD). Overexpression of caspase-1 can induce apoptosis . Mice deficient in caspase-1, however, have no overt defects in apoptosis but do have defects in the maturation of pro-IL-1ß and are resistant to endotoxic shock . At least six caspase-1 isoforms have been identified, including caspase-1 a, ß, ?, d, e and ? . Most caspase-1 isoforms (a, ß, ? and d) produce products between 30-48 kDa and induce apoptosis upon over-expression. Caspase-1 e typically contains only the p10 subunit, does not induce apoptosis and may act as a domint negative. The widely expressed ? isoform of caspase-1 induces apoptosis and lacks 39 amino-termil residues found in the a isoform (6). Activation of caspase-1 occurs through an oligomerization molecular platform desigted the "inflammasome" that includes caspase-5, Pycard/Asc, and LP1 .
General readings
Enari et al. Nature 375: 78, 1995.
Walker et al. Cell 78: 343, 1994.

















































- Quick-Filters:
- Highly Validated (1)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA336409 | Caspase-1 antibody |
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| Mouse Monoclonal Caspase-1 Antibody (14F468) | |||||||
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Mouse | IgG1 | 14F468 | Purified | Hu, Ms | C, P, WB |
0.1 mg /
€450.00
|
| OriGene Technologies, Inc. | |||||||
+5 additional images |
Highly validated antibody! |
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| TA306199 | Caspase-1 (C-term) antibody |
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| Rabbit Polyclonal Caspase-1 Antibody | |||||||
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Rabbit | IgG | Aff - Purified | Hu | E, P, WB |
0.1 mg /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA306200 | Caspase-1 antibody |
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| Rabbit Polyclonal Caspase-1 Antibody | |||||||
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Rabbit | IgG | Aff - Purified | Hu | E, P, WB |
0.1 mg /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| TA312620 | Caspase-1 antibody |
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| Rabbit polyclonal Caspase 1 (Cleaved-Asp210) antibody | |||||||
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Rabbit | IgG | Purified | Hu | E, P, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA312621 | Caspase-1 antibody |
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| Rabbit polyclonal Caspase 1 (Cleaved-Asp210) antibody | |||||||
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Rabbit | IgG | Purified | Hu | E, P |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA312622 | Caspase-1 antibody |
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| Rabbit polyclonal CASP1 (p20, Cleaved-Asn120) antibody | |||||||
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Rabbit | IgG | Purified | Hu | E, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA312624 | Caspase-1 antibody |
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| Rabbit polyclonal Caspase 1 (p10, Cleaved-Ala317) antibody | |||||||
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Rabbit | IgG | Purified | Hu | E, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA312625 | Caspase-1 antibody |
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| Rabbit polyclonal Caspase 1 (Ser376) antibody(Phospho-specific) | |||||||
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Rabbit | IgG | Purified | Hu, Ms | E, P, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA323204 | Caspase-1 antibody |
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| Anti-CASP1 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, P, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA326866 | Caspase-1 antibody |
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| CASP1 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA336408 | Caspase-1 antibody |
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| Rabbit Polyclonal Caspase-1 Antibody | |||||||
![]() |
Rabbit | Purified | Hu | WB |
0.1 mg /
€335.00
|
||
| OriGene Technologies, Inc. | |||||||
+1 additional image |
|||||||
| TA348018 | Caspase-1 antibody |
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| Rabbit Polyclonal Anti-Caspase 1 Antibody | |||||||
![]() |
Rabbit | IgG | Purified | Hu, Ms | WB |
0.1 mg /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA348921 | Caspase-1 antibody |
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| Rabbit Polyclonal Anti-Caspase 1 (Phospho-Ser376) Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms | WB |
0.1 mg /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| AP06610PU-N | Caspase-1 antibody |
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Rabbit | Aff - Purified | Hu, Ms | P, WB |
0.1 mg /
€370.00
|
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| OriGene Technologies GmbH | |||||||
| AP22755PU-N | Caspase-1 antibody |
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Rabbit | Purified | Hu | P |
0.25 ml /
€425.00
|
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| OriGene Technologies GmbH | |||||||
| AP22860PU-N | Caspase-1 (C-term) antibody |
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Rabbit | Purified | Hu | E, P, WB |
50 µg /
€425.00
|
||
| OriGene Technologies GmbH | |||||||
+2 additional images |
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| AP22861PU-N | Caspase-1 antibody |
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![]() |
Rabbit | Purified | Hu | E, P, WB |
50 µg /
€425.00
|
||
| OriGene Technologies GmbH | |||||||
+2 additional images |
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| DP064 | Caspase-1 antibody |
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Rabbit | Purified | Hu, Ms, Rt | P, WB |
1 ml /
€1,080.00
|
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| OriGene Technologies GmbH | |||||||
| DP064-05 | Caspase-1 antibody |
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Rabbit | Purified | Hu, Ms, Rt | P, WB |
0.5 ml /
€680.00
|
||
| OriGene Technologies GmbH | |||||||
| SP2146P | Caspase-1 (C-term) antibody |
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![]() |
Rabbit | Purified | Hu | P, WB |
0.1 mg /
€410.00
|
||
| OriGene Technologies GmbH | |||||||
+1 additional image |
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![Western Blot: Caspase 1 Antibody (14F468) [TA336409] - analysis of Caspase-1 using a Caspase-1 monoclonal antibody. Human HeLa (A) and mouse NIH3T3 lysate probed with Caspase-1 antibody at 0.5 ug/ml and 2 ug/ml, respectively.](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/OriGene/NB100-56565-1-W.jpg)
+5 additional images








![Western Blot: Caspase 1 Antibody [TA336408] - analysis of Caspase-1 using a polyclonal antibody. Human HeLa lysate probed with Caspase-1 antibody at 0.5 ug/ml.](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/OriGene/NB100-56564-1-W.jpg)







