Caspase-9 antibody
Principal name
Caspase-9 antibody
Alternative names for Caspase-9 antibody
CASP-9, CASP9, MCH6, ICE-LAP6, APAF-3, APAF3, ICE-like apoptotic protease 6, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3
Ncbi ID
NP_001220.2, NP_001220, 9606, NP_056548, ABM82619.1, NM_001229, NM_032996, NP_127463, P55211, NP_056548.2, NM_015733
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E)
Background of Caspase-9 antibody
Caspase 9 (also known as ICE-like apoptotic protease 6 (ICE-LAP6), apoptotic protease Mch-6, and apoptotic protease activating factor 3 (Apaf-3)) is a member of the peptidase family C14 that contains a CARD domain. This caspase is active as a heterotetramer and has been reported to have two isoforms. Pro-Caspase 9 has been reported to be approximately 47 kD. This caspase is present in the cytosol and, upon activation, translocates to the mitochondria. Caspase 9 is involved in the caspase activation cascade responsible for apoptosis execution and cleaves/activates Caspase 3 and Caspase 6. Caspase 9 is inhibited by the dominant negative isoform, Bcl-XL, c-IAP1, c-IAP2, XIAP, and Livin. This caspase becomes activated when recruited to Apaf-1/cytochrome c complex, and following cleavage by Apaf-1, granzyme B, Caspase 3, possibly Caspase 8 and Caspase 10 into large p37 and small p10 subunits. Caspase 9 interacts with BIRC7 and has been shown to cleave PARP and vimentin.
Structure: Peptidase family C14, CARD domain. Heterotetramer, two isoforms, pro-Casp9 47 kD, active cleaved from Casp9 37 kD.
Distribution: Cytoplasm, when activated mitochondrial.
Function: Involved in caspase activation cascade responsible for apoptosis execution; cleaves/activates Casp3, Casp6.
Regulation: Inhibited by dominant negative isoform, Bcl-XL, c-IAP1, c-IAP2, XIAP, Livin. Activated when recruited to Apaf-1/cytochrome c complex, cleaved by Apaf-1, granzyme B, Casp3, possibly Casp8 and -10 into large p37 and small p10 subunits.
Interaction: BIRC7; cleaves PARP, vimentin.





























Western blot analysis of Caspase-9 fragments expression in apoptosis induced Jurkat cells by anti-Fas monoclonal antibody using AM26603AF-N. AM26603AF-N react with pro-caspase-9, Intermediate form and active form.














































- Quick-Filters:
- Highly Validated (1)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| AP22914PU-N | Caspase-9 (299-318) antibody |
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Rabbit | Purified | Hu | E, ICC/IF, P, WB |
50 µg /
€425.00
|
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| OriGene Technologies GmbH | |||||||
+3 additional images |
Highly validated antibody! |
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| TA305982 | Caspase-9 antibody |
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| Rabbit Polyclonal Caspase-9 Antibody | |||||||
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Rabbit | IgG | Aff - Purified | Hu, Ms, Rt | E, WB |
0.1 mg /
€415.00
|
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| OriGene Technologies, Inc. | |||||||
| TA305983 | Caspase-9 antibody |
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| Rabbit Polyclonal Caspase-9 Antibody | |||||||
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Rabbit | IgG | Aff - Purified | Hu | E, ICC/IF, WB |
0.1 mg /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| TA308861 | Caspase-9 antibody |
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| Rabbit polyclonal antibody to Caspase-9 (caspase 9, apoptosis-related cysteine peptidase) | |||||||
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Rabbit | IgG | Aff - Purified | Hu | WB |
0.1 ml /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA309596 | Caspase-9 antibody |
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| Mouse Monoclonal Caspase 9 Antibody (LAP6 96-2-22) | |||||||
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Mouse | IgG1 | LAP6 96-2-22 | Purified | Hu | WB |
0.2 ml /
€415.00
|
| OriGene Technologies, Inc. | |||||||
| TA312629 | Caspase-9 antibody |
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| Rabbit polyclonal Caspase 9 (Cleaved-Asp315) antibody | |||||||
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Rabbit | IgG | Purified | Hu | E, P, WB |
0.1 ml /
€335.00
|
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| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA312634 | Caspase-9 antibody |
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| Rabbit polyclonal Caspase 9 (Thr125) antibody(Phospho-specific) | |||||||
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Rabbit | IgG | Purified | Hu, Ms | E, P, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA312637 | Caspase-9 antibody |
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| Rabbit polyclonal Caspase 9 (Tyr153) antibody(Phospho-specific) | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, ICC/IF, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA321307 | Caspase-9 antibody |
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| Anti-CASP9 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, P |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA321308 | Caspase-9 antibody |
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| Anti-CASP9 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| TA321309 | Caspase-9 antibody |
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| Anti-CASP9 (active) Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, P |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA324765 | Caspase-9 antibody |
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| Rabbit polyclonal Phospho-Caspase 9(S196) Antibody | |||||||
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Rabbit | IgG | Purified | Hu | P, WB |
0.4 ml /
€415.00
|
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| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA325012 | Caspase-9 (Center) antibody |
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| Rabbit polyclonal CASP9 Antibody (Center) | |||||||
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Rabbit | Ig | Purified | Hu | WB |
0.4 ml /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| TA325297 | Caspase-9 antibody |
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| Rabbit Polyclonal Caspase 9 Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA325298 | Caspase-9 antibody |
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| Rabbit Polyclonal Caspase 9 (Thr125) Antibody (Phospho-specific) | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA327390 | Caspase-9 antibody |
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| Rabbit anti-CASP9 Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA336326 | Caspase-9 antibody |
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| Rabbit Polyclonal Caspase-9 Antibody | |||||||
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Rabbit | Purified | Can, Ge, Hu, Ms, Rt | IP, P |
50 µl /
€415.00
|
||
| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| TA336327 | Caspase-9 antibody |
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| Rabbit Polyclonal Caspase-9 Antibody | |||||||
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Rabbit | Purified | Can, Ge, Hu, Ms, Rt | IP, P, WB |
50 µl /
€395.00
|
||
| OriGene Technologies, Inc. | |||||||
+2 additional images |
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| TA346902 | Caspase-9 antibody |
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| Mouse Monoclonal Caspase-9 Antibody | |||||||
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Mouse | IgG1 | 1D1-F2-E9 | Purified | WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
+1 additional image |
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| TA347933 | Caspase-9 antibody |
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| Rabbit Polyclonal Anti-Caspase 9 (Cleaved-Asp353) Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||














































+3 additional images














![Immunohistochemistry-Paraffin: Caspase 9 Antibody [TA336326] - Analysis Human Brain sections stained for cleaved Caspase-9 expression using this antibody at 1:2000. A. Section from a patient 24 hr after head trauma. B. Control: section from a patient with](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/OriGene/NB100-56118-1-H.jpg)
![Simple Western: Caspase 9 Antibody [TA336327] - Simple Western lane view shows a specific band detected for Caspase 9 in HeLa lysate. This experiment was performed under reducing conditions using the Wes or Sally Sue separation system 12-230kDa (or 66-44](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/OriGene/NB100-56119-1-W.jpg)

