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CD38 antibody

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Principal name

CD38 antibody

Alternative names for CD38 antibody

cADPr hydrolase 1, T10, ADP-ribosyl cyclase 1, Cyclic ADP-ribose hydrolase 1

SwissProt ID

P28907 (Human), P56528 (Mouse), Q64244 (Rat)

Gene ID

12494 (Cd38), 952 (CD38), 25668

Ncbi ID

NP_031672.2, NP_001766.2, 9606, 10090, NP_001766, NM_001775, NM_013127

Available reactivities

Ms (Mouse), Hu (Human), Mky (Monkey), Rt (Rat)

Available hosts

Rat, Mouse, Rabbit, Goat

Available applications

Frozen Sections (C), Flow Cytometry (F), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Enzyme Immunoassay (E), Functional assay (FN), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CD38 antibody

CD38 (T10) is a single chain 42 to 46 kDa type II integral transmembrane glycoprotein with a short N terminal cytoplasmic tail. CD38 is highly expressed on thymocytes. It is also expressed by early cells of B and T lineages, NK cells, plasma cells, monocytes and macrophages and may be detected on cells from multiple myeloma, ALL (B and T) and some AML. It is expressed by murine, but not human, hematopoietic progenitors. In normal lymph nodes and tonsils the antigen is detected mainly on B cells in germinal centers and in plasma cells. The extracellular domain of the molecule shares a high homology sequence with Aplysia ADP ribosyl cyclase. CD38 functions as a multicatalytic ectoenzyme serving as ADP ribosyl cyclase, ADPR hydrolase and possibly NAD+ glycohydrolase, or as a surface receptor. In mice, CD38 is expressed by follicular B cells, is down regulated on germinal centre B cells, and is not expressed by mature plasma cells. Murine CD38 is also expressed by all Mac1+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone marrow derived macrophages. This pattern of expression contrasts strikingly with that seen in the human. Monoclonal antibodies to CD38 have been shown to be useful in subtyping of lymphomas and leukemias, inhibition of B lymphopoiesis, detection of plasma cells, protection of B cells from apoptosis, and as a marker for activated B and T cell proliferation.

General readings

1. Harada, N., L. Santos-Argumedo, R. Chang, J. C. Grimaldi, F. E. Lund, C. I. Brannan, N. G. Copeland, N. A. Jenkins, A. W. Heath, and R. M.
Parkhouse. 1993. J. Immunol. 151:3111.
2. Santos-Argumedo, L., C. Teixeira, G. Preece, P. A. Kirkham, and R. M. E. Parkhouse. 1993. J. Immunol. 151:3119.
3. Howard, M., J. C. Grimaldi, J. F. Bazan, F. E. Lund, L. Santos-Argumedo, R. M. E. Parkhouse, T. F. Walseth, and H. C. Lee. 1993. Science 262:1056.
4. Lund, F., N. Solvason, J. C. Grimaldi, R. M. Parkhouse, and M. Howard. 1995. Immunol. Today 16:469.
5. Kirkham, P. A., L. Santos-Argumedo, M. M. Harnett, and R. M. Parkhouse. 1994. Immunology 83:513.
6. Bean, A. G. D., D. I. Godfrey, W. G. Ferlin, L. Santos-Argumedo, R. M. E. Parkhouse, M. C. Howard, and A. Zlotnik. 1996. Int. Immunol. 7:213.
7. Oliver, A. and J. Kearney. 1996. Personal Communication.
8. Kumagai, M., E. Coustan-Smith, D. J. Murray, O. Silvennoinen, K. G. Murti, W. E. Evans, F. Malavasi, and D. Campana. 1995. J. Exp. Med. 181:1101.

SM028B - CD38
SM3083P - CD38
Surface staining of PHA stimulated Human peripheral blood lymphocytes with PE conjugated anti-Human CD38 Antibody Cat.-No SM3083P (Clone HIT2).
SM3083P - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) PE-CyTM5.
SM3083P - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) PE-CyTM7.
SM3083P - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) FITC.
SM3083P - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) Alexa Fluor® 700.
SM1106A - CD38
Staining of Human peripheral blood monocytes with Mouse Anti Human CD38-Azide Free (Cat.-No SM1106A).
SM1106B - CD38
Staining of human peripheral blood lymphocytes with Mouse Anti Human CD38-Biotin (SM1106B/BT).
SM1106F - CD38
Staining of human peripheral blood monocytes using Mouse Anti Human CD38-FITC
SM1106R - CD38
Staining of human peripheral blood monocytes with Mouse Anti Human CD38-RPE.
SM3083C - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) FITC.
SM3083C - CD38
Surface staining of PHA stimulated human peripheral blood lymphocytes with anti-human CD38 (HIT2) PE.
H00000952-M02 - CD38
Detection limit for recombinant GST tagged CD38 is approximately 0.3ng/ml as a capture antibody.
SM3083B - CD38
Surface staining of PHA stimulated human peripheral blood lymphocytes with anti-human CD38 (HIT2) PE.
SM3083B - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) PE-CyTM5.

SM3083B - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) PE-CyTM7.
SM3083B - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) FITC.
SM3083B - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) Alexa Fluor® 700.
SM3083F - CD38
Surface staining of PHA stimulated human peripheral blood lymphocytes with anti-human CD38 (HIT2) PE.
SM3083F - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) PE-CyTM5.
SM3083F - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) PE-CyTM7.
SM3083F - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) FITC.
SM3083F - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) Alexa Fluor® 700.
SM3083R - CD38
Surface staining of PHA stimulated Human peripheral blood lymphocytes with PE conjugated anti-Human CD38 antibody (HIT2).
SM3083R - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) PE-CyTM5.
SM3083R - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) PE-CyTM7.
SM3083R - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) FITC.
SM3083R - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) Alexa Fluor® 700.
SM3083APC - CD38
Surface staining of PHA stimulated human peripheral blood lymphocytes with anti-human CD38 (HIT2) PE.
SM3083APC - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) PE-CyTM5.
SM3083APC - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) PE-CyTM7.
SM3083APC - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) FITC.
SM3083APC - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) Alexa Fluor® 700.
AM08041FC-N - CD38
Immunofluoscent Staining: BALB/c spleen cells were double-stained with Rat anti-Mouse CD38-R-PE and Rat anti-Mouse CD19-FITC (clone 6D5). Lymphocytes were gated and analyzed on a FACScan(TM) flow cytometer (BDIS, San Jose, CA). Amount Used: 0.3 µg/10e6 cells.
MAB3836 - CD38
Surface staining of PHA stimulated human peripheral blood lymphocytes with CD38 monoclonal antibody, clone HIT2 ( Cat # MAB3836 ) conjugated with PE.
MAB5606 - CD38
Cells from BALB/c spleen were double-stained with Cd38 monoclonal antibody-FITC and hamster anti-mouse CD3-R-PE. Small lymphocytes were gated and analyzed on a FACScan flow cytometer ( BDIS, San Jose, CA ).
ARP59103_P050 - CD38
Human Jurkat; WB Suggested Anti-CD38 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Jurkat cell lysate; CD38 antibody - C-terminal region (ARP59103_P050) in Human Jurkat cells using Western Blot
AM20475SU-N - CD38
Spleen, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)
AM20475SU-N - CD38
Tonsil, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)
AM20475SU-N - CD38
Western blot analysis using Monoclonal CD38 antibody against CD38-hIgGFc transfected HEK293 cell lysate.
AM39017AC-N - CD38
Representative DataAnti-CD38, clone T16, was analyzed by flow cytometry using a blood sample from a healthy donor.The cytogram shows direct staining with 10 µl anti-CD38 R-PE per 100 µl whole blood.
AM06390SU-N - CD38
Immunohistochemical analysis of paraffin-embedded human lung cancer (A), lymphonodus tissue (B),showing cytomembrane localization using CD38 mouse mAb with DAB staining.
AM06390SU-N - CD38
Western blot analysis using CD38 mouse mouse mAb against CD38-hIgGFc transfected HEK293 cell lysate.
SM3083PP - CD38
Surface staining of PHA stimulated human peripheral blood lymphocytes with anti-human CD38 PE (SM3083R).
SM3083PP - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) PE-CyTM5.
SM3083PP - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) PE-CyTM7.
SM3083PP - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) FITC.
SM3083PP - CD38
Surface staining of human peripheral blood with anti-human CD38 (HIT2) Alexa Fluor® 700.
AM33211PU-S - CD38
Flow Cytometric analysis of anti-CD38 Antibody Cat.-No AM33211PU (Clone 149) in HeLa (green) compare to negative control of rabbit IgG (blue)
AM33211PU-S - CD38
Human Tonsil stained with anti-CD38 Antibody Cat.-No AM33211PU (Clone SP149)
CPA8319-50Assays - CD38
Flow cytometric analysis of human lymphocytes treated with PHA and ConA using Anti-CD38 Antibody-APC labled.
CPA8360-50Assays - CD38
Flow cytometric analysis of human lymphocytes treated with PHA and ConA using Anti-CD38 Antibody-FITC labled.
CPA8432-50Assays - CD38
Flow cytometric analysis of human lymphocytes treated with PHA and ConA using Anti-CD38 Antibody-PE labled.
CPA8474-50Assays - CD38
Flow cytometric analysis of human lymphocytes treated with PHA and ConA using Anti-CD38 Antibody-PE-Cy5 labled.
CPA8523-100ul - CD38
Flow cytometric analysis of human lymphocytes treated with PHA and ConA using Anti-CD38 Antibody; followed by anti-mouse IgG PE.
TA320266 - CD38
Staining of BALB/c splenocytes with 0.06 ug of Rat IgG2a Isotype Control Purified (open histogram) or 0.06 ug Anti-Mouse CD38 Purified (filled histogram) followed by Anti-Rat IgG FITC . Total viable cells were used for analysis.
TA324750 - CD38
Western blot analysis of lysate from RPMI 8226 cell line, using CD38 Antibody (C-term)(Cat. #TA324750). TA324750 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
TA324750 - CD38
Formalin-fixed and paraffin-embedded human hepatocarcinoma with CD38 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
TA324750 - CD38
Immunofluorescence analysis of CD38 Antibody (C-term) with paraffin-embedded human hepatocarcinoma tissue . 0.05 mg/ml primary antibody was followed by FITC-conjugated goat anti-rabbit lgG (whole molecule). FITC emits green fluorescence.Red counterstaining is PI.
TA324750 - CD38
Confocal immunofluorescent analysis of CD38 Antibody (C-term) (Cat. #TA324750) with Hela cell followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
TA324750 - CD38
Flow cytometric analysis of HepG2 cells using CD38 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
TA326737 - CD38
TA326737 (2µg/ml) staining of Human Spinal Cord cancer lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
TA341220 - CD38
Anti-CD38 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
TA341220 - CD38
Anti-CD38 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
TA341221 - CD38
Anti-CD38 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
AR52066PU-N - CD38
TA352698 - Cd38
C57BL/6 splenocytes stained with purified 90, followed by anti-rat IgG FITC
TA352678 - CD38
Human peripheral blood lymphocytes stained with purified HIT2, followed by anti-mouse IgGs FITC
TA351051 - CD38
Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-2: A549 cells, Raji cells, Primary antibody: (CD38 Antibody) at dilution 1/520, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
TA351051 - CD38
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (CD38 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200)
TA351051 - CD38
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using (CD38 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD38 antibody
  Rabbit polyclonal CD38 Antibody (C-term)  
Western blot analysis of lysate from RPMI 8226 cell line, using CD38 Antibody (C-term)(Cat. #TA324750). TA324750 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug. Rabbit IgG Purified Hu, Mky F, ICC/IF, P, WB
0.4 ml / €415.00
  OriGene Technologies, Inc.
+4 additional images

Highly validated antibody!

CD38 (226-237) antibody
  Goat Anti-CD38 (aa226-237) Antibody  
TA326737 (2µg/ml) staining of Human Spinal Cord cancer lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €360.00
  OriGene Technologies, Inc.

CD38 antibody
  Rabbit Polyclonal Anti-CD38 Antibody (C-Terminus)  
Anti-CD38 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €425.00
  OriGene Technologies, Inc.
+1 additional image

CD38 antibody
  Rabbit Polyclonal Anti-CD38 Antibody (Internal)  
Anti-CD38 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €425.00
  OriGene Technologies, Inc.

CD38 antibody
  Rabbit Polyclonal Anti-CD38 Antibody  
Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-2: A549 cells, Raji cells, Primary antibody: (CD38 Antibody) at dilution 1/520, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.
+2 additional images

5 Item(s)

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  1. Primary Antibody (5)
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  3. Mouse (Ms) (1)
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  1. Western blot / Immunoblot (WB) (3)
  2. Enzyme Immunoassay (E) (2)
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