Galectin-3 antibody

Principal name

Galectin-3 antibody

Alternative names for Galectin-3 antibody

Mac-2, Lgals3, GAL3, GALBP, CBP35, L-31, Galactose-specific lectin 3, IgE-binding protein, 35 kDa lectin, Carbohydrate-binding protein 35, Laminin-binding protein, Lectin L-29, L-34 galactoside-binding lectin

SwissProt ID

P08699 (Rat), P16110 (Mouse), P17931 (Human), P38486, P47845 (Rabit)

Gene ID

3958 (LGALS3), 16854 (Lgals3), 404021

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat, Rat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Functional assay (FN), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Luminex (LMNX)

Background of Galectin-3 antibody

Galectin-3 is a member of the galectin family. The protein is composed of three domains: a small amino-terminal domain, a carboxyl-terminal carbohydrate recognition domain (CRD) and amino-terminal domain containing repeating elements. Galectin-3 is normally distributed in epithelia of many organs and various inflammatory cells, including macrophages, as well as dendritic cells and Kupffer cells. The expression of this lectin is up-regulated during inflammation, cell proliferation, cell differentiation and through trans-activation by viral proteins. The expression is also affected by neoplastic transformation: up-regulated in certain types of lymphomas and thyroid carcinoma, while down-regulated in other types of malignancies, such as colon, breast, ovarian and uterine carcinomas.
Galectin-3 has been shown to function through both intracellular and extracellular actions. Related to its intracellular functions, galectin-3 has been identified as a component of heterogeneous nuclear ribonuclear protein (hnRNP), a factor in pre-mRNA splicing, and has been found to control cell cycle and prevent T cell apoptosis. On the other hand, this protein has also been demonstrated to function as extracellular molecule in activating various types of cells, including monocytes/macrophages, mast cells, neutrophils and lymphocytes. Galectin-3 has been shown to mediate cell-cell and cell-extracellular matrix interactions.

General readings

1. Ma F  et al. The requirement of CD8+ T cells to initiate and augment acute cardiac inflammatory response to high blood pressure. J Immunol 192:3365-73 (2014). IHC-P,ICC/IF ; Mouse .PubMed: 24600037
2. Lee YJ  et al. Spatial and temporal expression, and statin responsiveness of galectin-1 and galectin-3 in murine atherosclerosis. Korean Circ J 43:223-30 (2013). IHC-FoFr ; Mouse .PubMed: 23682281
3. Reticker-Flynn NE  et al. A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis. Nat Commun 3:1122 (2012).WB .PubMed: 23047680
4. Doe JA  et al. Transgenic overexpression of the a7 integrin reduces muscle pathology and improves viability in the dy(W) mouse model of merosin-deficient congenital muscular dystrophy type 1A. J Cell Sci 124:2287-97 (2011). WB, IHC-Fr ; Mouse .PubMed: 21652631
5. Checinska A  et al. Comparative proteomics analysis of caspase-9-protein complexes in untreated and cytochrome c/dATP stimulated lysates of NSCLC cells. J Proteomics 72:575-85 (2009).PubMed: 19118655

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Galectin-3 antibody

Section of cartilage, showing immunostaining for galectin-3 from normal (A-C) and OA cartilage (D-F).
A and D: non immune serum
B, C, E and F: polclonal anti-galectin-3

Dilution: 1/2500
C = cytosol Rabbit Serum Hu C, E, WB
0.2 ml / €430.00
  OriGene Technologies GmbH

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