GPR75 antibody

Background of GPR75 antibody

Recently a novel human G-protein coupled receptor gene has been characterized and mapped to chromosome 2p16. This gene codes for a 540 amino acid protein in retinal pigment epithelium (RPE) and cells surrounding retinal arterioles. In contrast, the Northern blot data obtained from mouse sections suggest the expression of transcripts in photoreceptor inner segments and I outer plexiform layer. The transcripts of the GPCR-75 gene (7kb) are also found in abundance in brain sections. So far, no mutations in GPCR-75 protein were identified in patients suffering from Doyne’s honeycomb retinal dystrophy (DHRD), an inherited retinal degeneration disease that maps to chromosome 2p16 (1).
The GPCR-75 protein is approximately 78 kDa (540 amino acids) protein that is primarily expressed in human retinal pigment epithelium (RPEs). The GPCR-75 sequence analyses suggest the presence of 7 trans-membrane domains, a characteristic feature of GPCR. The protein has putative N-glycosylation sites near the extra cellular N-terminal end of the proteins. The protein has a large 3 intra cellular loop which might be the site for interaction of G-proteins. The short carboxy terminal is intracellular and has putative post-translational modification lipid modification sites.