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KCNC2 antibody

Principal name

KCNC2 antibody

Alternative names for KCNC2 antibody

Potassium voltage-gated channel subfamily C member 2, Voltage-gated potassium channel Kv3.2

SwissProt ID

P22462 (Rat), Q14B80 (Mouse), Q96PR1 (Human)

Gene ID

3747 (KCNC2), 246153 (Kcnc2)

Ncbi ID

NP_631874.1, NP_631874, NM_153748, NP_631962.1, NM_139137

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Por (Porcine)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Frozen Sections (C)

Background of KCNC2 antibody

Kv3.2 is a member of the voltage-gated K+ channel superfamily. Together with the related proteins Kv3.1, Kv3.3 and Kv3.4 they constitute the Shaw type subfamily family. As with all Kv channels, Kv3.2 possesses the sigture structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. The functiol Kv channel is a tetramer that can either be a homomer or a heteromer of Kv3 subunits. Kv3 subfamily members ictivate very rapidly and therefore are thought to play a role in the repolarization of action potentials and to facilitate repetitive high frequency firing. Kv3.2 is highly expressed in the brain but has been also detected in peripheral organs such as pancreas and mesenteric artery. Kv3.2 and Kv3.1 are highly enriched in neurons that fire at high frequencies, such as fast spiking interneurons of the cortex and hippocampus and neurons in the globus pallidus. Their unusually rapid activation and deactivation rates allow channels containing Kv3.2 and Kv3.1 subunits to repolarize action potentials quickly thus minimizing the rate of recovery of sodium channel ictivation.

Immunohistochemistry (IHC) analyzes of Potassium Channel Kv3.2b/Kcnc2 antibody (Cat.-No.: AP06289PU-N) in paraffin-embedded human brain tissue.

AP06289PU-N

Western blot (WB) analysis of Potassium Channel Kv3.2b/Kcnc2 antibody (Cat.-No.: AP06289PU-N) in extracts from HepG2 cells.

AP06289PU-N

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Potassium Channel Kv3.2b Antibody. The picture on the right is treated with the synthesized peptide.

Western blot analysis of extracts from HepG2 cells, using Potassium Channel Kv3.2b Antibody. The lane on the right is treated with the synthesized peptide.

Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

AP31609PU-N

Western blot analysis of extracts from HepG2 cells, using KCNC2 antibody. The lane on the right is treated with the synthesized peptide.

AP31609PU-N

Western blot analysis of Kv3.2 expression in U251MG (A) whole cell lysates.

Western blot analysis of extracts from HepG2 cells, using Potassium Channel Kv3.2b antibody (#TA314124).The lane on the right is treated with the synthesized peptide.

TA314124

Western blot analysis of extracts from 293 cells (Lane 2), using Potassium Channel Kv3.2b Antibody. The lane on the left is treated with synthesized peptide.

TA314124

Immunohistochemical analysis of paraffin-embedded human brain tissue using Potassium Channel Kv3.2b antibody (#TA314124).The picture on the right is treated with the synthesized peptide.

TA314124

Predicted band size: 62 kDa . Positive control: 231 cell and human brain malignant glioma tissue lysate. Recommended dilution: 1/200-1000. (Gel: 8%SDS-PAGE Lane1: 231 cell lysate Lane2: Human brain malignant glioma tissue lysate Lysates: 50 ug per lane Primary antibody: 1/450 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 seconds)

TA322053

Predicted cell location: Cytoplasm. Positive control: Human liver and colon cancer tissue. Recommended dilution: 1/150-500 The image on the left is immunohistochemistry of paraffin-embedded Human liver and colon cancer tissue using KCNC2 antibody at dilution 1/100, on the right is treated with the synthetic peptide. (Original magnification:x200)

TA322054

TA322054

Western blot analysis of rat brain membranes: 1. Anti-Kv3.2 antibody , (1:200). 2. Anti-Kv3.2 antibody, preincubated with the control peptide antigen.

TA328930

Western blot analysis on HepG2 cell lysate using KCNC2 Antibody

TA347462

Primary Antibodies

Catalog No.	Host	Iso.	Pres.	React.	Applications
TA314124	KCNC2 antibody
	Rabbit polyclonal Potassium Channel Kv3.2b antibody
	Rabbit	IgG	Purified	Hu, Ms, Rt	E, P, WB	0.1 ml / €335.00
						OriGene Technologies, Inc.
+2 additional images
TA322053	KCNC2 antibody
	Anti-KCNC2 Rabbit Polyclonal Antibody
	Rabbit	IgG	Purified	Hu, Ms, Rt	E, WB	0.1 ml / €335.00
						OriGene Technologies, Inc.
TA322054	KCNC2 antibody
	Anti-KCNC2 Rabbit Polyclonal Antibody
	Rabbit	IgG	Purified	Hu, Ms, Rt	E, P	0.1 ml / €335.00
						OriGene Technologies, Inc.
+1 additional image
TA328930	KCNC2 antibody
	Rabbit polyclonal Anti-KV3.2
	Rabbit		Purified	Hu, Ms, Rt	WB	0.2 ml / €585.00
						OriGene Technologies, Inc.
TA347462	KCNC2 antibody
	Rabbit Polyclonal Anti-KCNC2 Antibody
	Rabbit	IgG	Purified	Hu, Ms, Rt	WB	0.1 mg / €335.00
						OriGene Technologies, Inc.
AP06289PU-N	KCNC2 antibody
	Rabbit		Aff - Purified	Hu, Ms, Rt	P, WB	0.1 mg / €370.00
						OriGene Technologies GmbH
+1 additional image
AP31609PU-N	KCNC2 (C-term) antibody
	Rabbit	IgG	Purified	Hu, Ms, Rt	E, P, WB	50 µl / €425.00
						OriGene Technologies GmbH
+1 additional image
AP55179PU-N	KCNC2 antibody
	Rabbit		Purified	Hu	C, E, WB	0.1 mg / €450.00
						OriGene Technologies GmbH