KCNC2 antibody
Principal name
KCNC2 antibody
Alternative names for KCNC2 antibody
Potassium voltage-gated channel subfamily C member 2, Voltage-gated potassium channel Kv3.2
Ncbi ID
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Frozen Sections (C)
Background of KCNC2 antibody
Kv3.2 is a member of the voltage-gated K+ channel superfamily. Together with the related proteins Kv3.1, Kv3.3 and Kv3.4 they constitute the Shaw type subfamily family. As with all Kv channels, Kv3.2 possesses the sigture structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. The functiol Kv channel is a tetramer that can either be a homomer or a heteromer of Kv3 subunits. Kv3 subfamily members ictivate very rapidly and therefore are thought to play a role in the repolarization of action potentials and to facilitate repetitive high frequency firing. Kv3.2 is highly expressed in the brain but has been also detected in peripheral organs such as pancreas and mesenteric artery. Kv3.2 and Kv3.1 are highly enriched in neurons that fire at high frequencies, such as fast spiking interneurons of the cortex and hippocampus and neurons in the globus pallidus. Their unusually rapid activation and deactivation rates allow channels containing Kv3.2 and Kv3.1 subunits to repolarize action potentials quickly thus minimizing the rate of recovery of sodium channel ictivation.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| AP06289PU-N | KCNC2 antibody |
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Rabbit | Aff - Purified | Hu, Ms, Rt | P, WB |
0.1 mg /
€370.00
|
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| OriGene Technologies GmbH | |||||||
 +1 additional image |
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| AP31609PU-N | KCNC2 (C-term) antibody |
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 |
Rabbit | IgG | Purified | Hu, Ms, Rt | E, P, WB |
50 µl /
€425.00
|
|
| OriGene Technologies GmbH | |||||||
| +1 additional image |
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