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Lactoperoxidase antibody

Principal name

Lactoperoxidase antibody

Alternative names for Lactoperoxidase antibody

LPO, SAPX, Lactoperoxidase, EC=1.11.1.7, Salivary peroxidase, SPO

SwissProt ID

P22079 (Human), P80025 (Bovin)

Gene ID

280844 (LPO), 4025

Ncbi ID

NP_776358, 9606, NM_006151, NM_001160102, NP_006142, NP_001153574.1

Available reactivities

Bov (Bovine), Hu (Human), Gt (Goat), Ms (Mouse), Sh (Sheep), Can (Canine), Rt (Rat), Prim (Primate)

Available hosts

Sheep, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Dot blot (Dot), Immunodiffusion (ID), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Radioimmunoassay (R)

Background of Lactoperoxidase antibody

Lactoperoxidase (LPO) is a heme-containing glycoprotein enzyme of about 78 kD molecular size expressed highly in mammary gland, salivary gland and bronchial submucosal glands, and consequently found in large amounts in secretory fluids such as milk, tears, saliva, and lung fluids. Lactoperoxidase belongs to mammalian peroxidase family with a prosthetic heme group covalently linked to the proteins and other members of this family include myeloperoxidase (MPO), eosinophil peroxidase (EPO), and thyroid peroxidase (TPO). In the presence of H2O2, lactoperoxidase oxidizes thiocyate (SCN-) more efficiently than other peroxidases, whereas MPO, EPO, and TPO most efficiently oxidize chloride, bromide, and iodide, respectively, to form hypo(pseudo)halides. After extracellular transport, SCN- gets oxidized either by peroxidases to form hypothiocyanite (OSCN-) or nonenzymatically by hypochlorite (OCl-). SCN exporters are the cystic fibrosis transmembrane conductance regulators, calcium-activated chloride channels, and pendrin/Slc26A4. OSCN- is tissue-innocuous but has a broad-spectrum microbicidal and microbistatic activity.

General readings

1. Everse J, Coates PW.
The cytotoxic activity of lactoperoxidase: enhancement and inhibition by neuroactive compounds.
Free Radic Biol Med. 2004 Sep 15;37(6):839-49.
PMID: 15384204

LPO polyclonal antibody ( Cat # PAB11546 ) ( 0.01 µg/ml ) staining of human lung lysate ( 35 µg protein in RIPA buffer ). Primary incubation was 1 hour. Detected by chemiluminescence.

PAB11546

Western blot analysis of LPO in MDA-MB-231 cell lysate using LPO polyclonal antibody ( Cat # PAB12397 ).

PAB12397

Western blot analysis of LPO in MDA-MB-231 cell lysate using LPO polyclonal antibody ( Cat # PAB12398 ).

PAB12398

TP318093

TA305848 (0.01ug/ml) staining of Human Lung lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

TA305848

Western Blot: Lactoperoxidase Antibody [TA336542] - Detection of LPO in MDA-MB231 cell lysate using TA336542.

TA336542

Western Blot: Lactoperoxidase Antibody [TA336543] - Detection of LPO in MDA-MB231 cell lysate

TA336543

Primary Antibodies

Catalog No.	Host	Pres.	React.	Applications
TA305848	Lactoperoxidase antibody
	Goat Anti-Lactoperoxidase Antibody
	Goat	Aff - Purified	Can, Hu, Ms, Rt	E, WB	0.1 mg / €360.00
					OriGene Technologies, Inc.
TA336542	Lactoperoxidase antibody
	Rabbit Polyclonal Lactoperoxidase Antibody
	Rabbit	Purified	Bov, Hu, Prim	WB	0.1 ml / €415.00
					OriGene Technologies, Inc.
TA336543	Lactoperoxidase antibody
	Rabbit Polyclonal Lactoperoxidase Antibody
	Rabbit	Purified	Bov, Gt, Hu, Ms, Sh	WB	0.1 ml / €300.00
					OriGene Technologies, Inc.
R1095	Lactoperoxidase antibody
	Sheep	Serum	Bov	E, WB	2 ml / €1,345.00
					OriGene Technologies GmbH
R1095BS	Lactoperoxidase antibody
	Sheep	Biotin	Bov	E, IP, WB	0.1 mg / €515.00
					OriGene Technologies GmbH
R1095HRPS	Lactoperoxidase antibody
	Sheep	HRP	Bov	E, IP, WB	0.1 mg / €515.00
					OriGene Technologies GmbH

Proteins & Growth Factors

Catalog No.	Species	Purity	Source
TP318093	Lactoperoxidase
	Recombinant protein of human lactoperoxidase (LPO)
	Human	> 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.	HEK293 cells	20 µg / €748.00
				OriGene Technologies, Inc.

Lysates

Catalog No.
LY416838	LPO overexpression lysate
		0.1 mg / €495.00
		OriGene Technologies, Inc.
LY431537	LPO overexpression lysate
		0.1 mg / €315.00
		OriGene Technologies, Inc.

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