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PDE9A antibody

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Principal name

PDE9A antibody

Alternative names for PDE9A antibody

Phosphodiesterase 9A, Phosphodiesterase PDE9A21, HSPDE9A2, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

SwissProt ID

O70628 (Mouse), O76083 (Human), Q86WN8 (Human)

Gene ID

5152 (PDE9A), 18585 (Pde9a)

Ncbi ID

NP_001001567, 9606, NP_001001567.1, NP_001001581, NM_002606, NM_001001569, NM_001001571, NM_001001574, NM_001001575, NM_001001576, NM_001001577, NM_001001578, NM_001001582, NM_001001583, NM_001001568, NP_001001578, NP_001001568, NP_001001574, NP_001157220.1, NM_008804, NM_001163748, NM_001001585, NM_001001567, NM_001001573, NM_001001581, NM_001001584, NM_001001572

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PDE9A antibody

Cyclic nucleotide phosphodiesterases (PDEs) are enzymes which catalyzes the hydrolysis of cyclic adenosine 30,50-monophosphate (cAMP) and/or cyclic guanosine 30,50-monophosphate (cGMP); and PDE9A (high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A) is a PDE member which hydrolyzes the second messenger cGMP, an important regulator of several critical cellular physiological processes. PDE9A activity gets modulated by metal ions and it can bind 2 divalent metal cations per subunit - site 1 binds zinc ions, whereas, site 2 preferentially associates with magnesium and/or manganese ions. PDE9A is expressed in most of the solid tissues and because of its location as well as contribution to the regulation of steady-state cellular concentrations of cyclic nucleotides, PDE9A has been suggested as a potential candidate for diseases such as bipolar affective disorder and its overexpression has been linked to Down syndrome. Moreover, PDE9A deficient mice fed a high-fat diet have been reported to exhibit a reduced weight gain and fat mass compared with wild-type mice.

General readings

Huai,Q., (2004) Proc. Natl. Acad. Sci. U.S.A. 101 (26), 9624-9629

AP00660SU-N - PDE9A
Western blot using AP00660SU-N (1:2,000) against lysate from Insect cells transfected with the indicated human PDE isoform.
H00005152-M01 - PDE9A
Immunoperoxidase of monoclonal antibody to PDE9A on formalin-fixed paraffin-embedded human cerebellum. [antibody concentration 3 ug/ml]
H00005152-B01P - PDE9A
Immunofluorescence of purified MaxPab antibody to PDE9A on HeLa cell. [antibody concentration 10 ug/ml]
H00005152-B01P - PDE9A
Western Blot analysis of PDE9A expression in transfected 293T cell line (H00005152-T01) by PDE9A MaxPab polyclonal antibody.Lane 1: PDE9A transfected lysate(58.63 KDa).Lane 2: Non-transfected lysate.
ARP45760_P050 - PDE9A
Human kidney; PDE9A Antibody (ARP45760_P050) in Human kidney cells using Immunohistochemistry
ARP45760_P050 - PDE9A
HEK293; . Sample Type :. Lane 1: 5ug in vitro translation without DNA Lane 2: 5ug in vitro translation hNeur1-pcDNA3 Lane 3: 60ug in vitro translation rNeur1-pcDNA3 Lane 4: 60ug HEK293 cell lysate (not transfected) Lane 5: 60ug hNeur1-pcDNA3 overexpressed in HEK293 cells Lane 6: 60ug rNeur1-pcDNA3 overexpressed in HEK293 cells . Primary Antibody Dilution :. 1:1000 . Secondary Antibody:. Anti-rabbit-HRP . Secondary Antibody Dilution:. 1:5000 . Color/Signal Descriptions:. PDE9A . Gene Name:. Kati Taal and Richard Tamme, Department of Gene Technology, Tallinn University of Technology. . Submitted by:.; PDE9A Antibody (ARP45760_P050) in HEK293 cells using Western Blot
ARP45760_P050 - PDE9A
Human Jurkat; WB Suggested Anti-PDE9A Antibody Titration: 1.0 ug/ml. Positive Control: Jurkat cell lysate; PDE9A Antibody (ARP45760_P050) in Human Jurkat cells using Western Blot
ARP45760_P050 - PDE9A
Mouse Brain; WB Suggested Anti-PDE9A Antibody Titration: 5% Milk. ELISA Titer: dilution: 1:500. Positive Control: Mouse Brain lysate; PDE9A Antibody (ARP45760_P050) in Mouse Brain cells using Western Blot
H00005152-B01 - PDE9A
Immunofluorescence of purified MaxPab antibody to PDE9A on HeLa cell. [antibody concentration 10 ug/ml]
H00005152-B01 - PDE9A
Western Blot analysis of PDE9A expression in transfected 293T cell line (H00005152-T01) by PDE9A MaxPab polyclonal antibody.Lane 1: PDE9A transfected lysate(58.63 KDa).Lane 2: Non-transfected lysate.
H00005152-D01P - PDE9A
Western Blot analysis of PDE9A expression in transfected 293T cell line (H00005152-T02) by PDE9A MaxPab polyclonal antibody.Lane 1: PDE9A transfected lysate(61.70 KDa).Lane 2: Non-transfected lysate.
AP10254PU-N - PDE9A
Western blot using AP10254PU-N (1:500).
AM31702PU-N - PDE9A
Human Adrenal Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
AM31702PU-N - PDE9A
Human Prostate, Epithelium: Formalin-Fixed, Paraffin-Embedded (FFPE)
AM31702PU-N - PDE9A
Detection limit for recombinant GST tagged PDE9A is 1 ng/ml as a capture antibody.
TP317127 - PDE9A
TP324133 - PDE9A
TP324417 - PDE9A
TA308688 - PDE9A
Sample (50 ug of whole cell lysate). A: Mouse brain. 7.5% SDS PAGE. TA308688 diluted at 1:1000.
TA308688 - PDE9A
Sample (30 ug of whole cell lysate). A: 293T. 7.5% SDS PAGE. TA308688 diluted at 1:3000
TA308688 - PDE9A
Immunohistochemical analysis of paraffin-embedded N87 xenograft, using PDE9A(TA308688) antibody at 1:500 dilution.
TA336701 - PDE9A
Western Blot: PDE9A Antibody [TA336701] - WB analysis of PDE9A in HeLa whole cell lysate.
TA336701 - PDE9A
Immunohistochemistry: PDE9A Antibody [TA336701] - PDE9A antibody was tested in mouse prostate using DAB with hematoxylin counterstain.
TA336701 - PDE9A
Immunocytochemistry/Immunofluorescence: PDE9A Antibody [TA336701] - PDE9A antibody was tested in NIH/3T3 cells with Dylight 488 (green). Nuclei were counterstained with DAPI (blue).
TA341105 - PDE9A
Anti-PDE9A antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PDE9A antibody
Human Adrenal Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 4E1 Purified Hu E, P, WB
50 µg / €475.00
  OriGene Technologies GmbH
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  2. Paraffin Sections (P) (1)
  3. Western blot / Immunoblot (WB) (1)
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  2. Paraffin Sections (P) (1)
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