PEX5L antibody

Background of PEX5L antibody

PEX5R (also called TRIP8b, tetratricopetide repeat-containing Rab8b-interacting protein) is a cytoplasmic protein expressed as a family of altertively spliced isoforms. PEX5R /TRIP8b isoforms contain a large constant domain preceded by a variable region. The C-termil half of TRIP8b comprises a tetratricopeptide repeat (TPR) protein binding domain. Alysis of the Pex5p-like protein revealed the presence of a tetratricopeptide repeat (TPR) domain in its C-termil half consisting of seven TPR motifs. Pex5R is almost exclusively expressed in brain. Recent studies provide strong evidence that PEX5R interacts with the carboxyl-termil region of Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and regulates their cell-surface expression level and cyclic nucleotide dependence. HCN channels are key modulators of neurol activity by providing the depolarizing cation current involved in rhythmogenesis, dendritic integration, and syptic transmission. In contrast, Gosh et al. have shown that human PEX5R can bind to peroxisomal targeting sigl-1 (PTS1) ligands. Furthermore it was shown that enzyme alanine–glyoxylate aminotransferase (AGT) is recognized by PEX5R in the cytoplasm, which allows its subsequent translocation into the peroxisome. TRIP8b may play a role in both normal neurol function and in aberrant neurol excitability associated with neurological diseases.