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PLVAP antibody

Principal name

PLVAP antibody

Alternative names for PLVAP antibody

Plasmalemma vesicle protein 1, PV1, PV-1, MECA-32 antigen, FELS, Endothelial cell marker, Endothelial cell surface marker, Endothelial Cell Antigen, Plasmalemma vesicle-associated protein, Fenestrated endothelial-linked structure protein

SwissProt ID

Q91VC4 (Mouse), Q9BX97 (Human), Q9WV78 (Rat)

Gene ID

83483 (PLVAP), 84094 (Plvap), 56765

Ncbi ID

9606, NP_112600, NP_112600.1, NM_031310, NM_032398, NM_020086, NP_115774.2

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P)

Background of PLVAP antibody

PLVAP is a 60kD protein which is otherwise known as MECA-32 and PV-1. PLVAP is a transmembrane homodimer which is associated with endothelial cell caveolae and fenestrae. In adult and embryonic mice, PLVAP is primarily expressed on endothelial tissues but shows restricted distribution in the skeletal, cardiac and brain tissues. In embryonic mice, PLVAP expression, on the vasculature associated with blood brain barrier has been reported to be developmentally regulated. In humans, PLVAP is selectively up-regulated in a variety of high-grade brain tumors, including glioblastoma and metastatic carcinoma, as well as other cerebral disorders associated with blood-brain barrier disruption, such as acute ischemia. PLVAP represents a novel marker of brain tumour angiogenesis and integrity of the blood-brain barrier and is a potential therapeutic target.

General readings

Keuschnigg, J., et al. Blood 114(2):478-484(2009)
Carson-Walter, E.B., et al. Clin. Cancer Res. 11(21):7643-7650(2005)
Strickland, L.A., et al. J. Pathol. 206(4):466-475(2005)
Stan, R.V., et al. Mol. Biol. Cell 15(8):3615-3630(2004)
Hnasko, R., et al. J. Endocrinol. 175(3):649-661(2002)
Stan, R.V., et al. Genomics 72(3):304-313(2001)
Stan, R.V., et al. J. Cell Biol. 145(6):1189-1198(1999)

Western blot analysis of PLVAP Antibody (Center) Cat.-No AP53357PU-N in HL-60 cell line lysates (35ug/lane). PLVAP (arrow) was detected using the purified Pab.

AP53357PU-N

Flow cytometric analysis of HL-60 cells using PLVAP Antibody (Center) Cat.-No AP53357PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis