PPP1CA antibody
Principal name
PPP1CA antibody
Alternative names for PPP1CA antibody
PPP1A, PP-1A, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
SwissProt ID
P62136 (Human), P62137 (Mouse), P62138 (Rat), P62139 (Rabit), Q3T0E7 (Bovin), Q8WMS6 (Canfa)
Ncbi ID
9606, NP_001008709.1, NP_002699, NP_001095176, NP_001008709, NM_002708, NM_001008709, NP_114074.1, NM_031868, NM_031527, NM_206873
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C)
Background of PPP1CA antibody
PPP1CA is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory.The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
General readings
1. Barker, H. M.; Jones, T. A.; da Cruz e Silva, E. F.; Spurr, N. K.; Sheer, D.; Cohen, P. T. W.: Localization of the gene encoding a type I protein phosphatase catalytic subunit to human chromosome band 11q13. Genomics 7: 159-166, 1990.
2 Genoux, D.; Haditsch, U.; Knobloch, M.; Michalon, A.; Storm, D.; Mansuy, I. M. : Protein phosphatase 1 is a molecular constraint on learning and memory. Nature 418: 970-975, 2002.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| AP55265SU-N | PPP1CA antibody |
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Rabbit | Serum | Hu | C, E, WB |
0.2 ml /
€430.00
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| OriGene Technologies GmbH | |||||||
