RNF216 antibody
Principal name
RNF216 antibody
Alternative names for RNF216 antibody
RING finger protein 216, TRIAD3, UBCE7IP1, ZIN, E3 ubiquitin-protein ligase RNF216, Triad domain-containing protein 3, Zinc finger protein inhibiting NF-kappa-B, Ubiquitin-conjugating enzyme 7-interacting protein 1
Ncbi ID
NP_996994.1, 9606, 5874, 10090, CAL37508.1, AAP47174, NM_207110, NM_207116, NM_207111
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)
Background of RNF216 antibody
Activation of NF-kappaB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses (reviewed in 1). Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 (2). Several regulatory mechanisms exist to control TLR signal transduction, including the inhibition of TLR expression and signaling by molecules such as ST2 and SIGIRR (3,4). Another mechanism is by the ubi-quitinization of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase (5). TRIAD3A is a RING finger protein that can bind to TLR4 and TLR9, and to a lesser extent TLR3 and TLR5, catalyzing the ubiquitization of these molecules. Overexpression of TRIAD3A promoted the nearly complete degradation of TLR4 and TLR9; this reduction was reflected in the decreased signal-specific activation by ligands specific for these TLRs. Conversely, depletion of TRIAD3A resulted in enhanced TLR activation (5).
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA306182 | RNF216 antibody |
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| Rabbit Polyclonal TRIAD3A Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms | E, P, WB |
0.1 mg /
€415.00
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| OriGene Technologies, Inc. | |||||||
 +2 additional images |
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