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SCN1A antibody

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Principal name

SCN1A antibody

Alternative names for SCN1A antibody

NAC1, SCN1, Sodium channel protein type 1 subunit alpha, Sodium channel protein type I subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.1, Sodium channel protein brain I subunit alpha

SwissProt ID

P04774 (Rat), P35498 (Human)

Gene ID

81574 (Scn1a), 6323 (SCN1A)

Ncbi ID

NP_110502, 10116, NP_001159435.1, NP_110502.1, NM_001165963

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of SCN1A antibody

Voltage-gated sodium channels (v) are essential for the generation of action potentials and for cell excitability. v channels are activated in response to depolarization and selectively allow flow of + ions. To date, nine v a subunits have been cloned and med v1.1-v1.9. The v channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (v1.1, v1.2, v1.3, v1.4, v1.6 and v1.7) and TTX-resistant (v1.5, v1.8 and v1.9). Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. + channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas + channels in adult skeletal muscle have only the β1 subunit. v1.1 is a highly tetrodotoxin-sensitive channel and is broadly expressed in neurons. Mutations in V1.1 are associated with at least two forms of epilepsy. Gain-of-function missense mutations are a primary cause of generalized epilepsy with febrile seizures plus (GEFS+). Loss-of-function mutations cause severe myoclonic epilepsy of infancy (SMEI).

AP15783PU-S - SCN1A
AP15783PU pan Sodium Channel antibody staining of Human Brain.
PAB11759 - SCN1A
Immunohistochemical staining of Scn1a on formalin fixed, paraffin embedded human cerebellum with Scn1a polyclonal antibody.
C0327-1 - SCN1A
Immunohistochemistry analysis of paraffin-embedded human heart tissue, using Sodium Channel-pan Antibody. The picture on the right is treated with the synthesized peptide.
C0327-1 - SCN1A
Western blot analysis of extracts from HuvEc cells, using Sodium Channel-pan Antibody. The lane on the right is treated with the synthesized peptide.
AP55276PU-N - SCN1A
Pancreas stained in IHC-P with SCN1A antibody
CPA2048-100ul - Nav1.1
Immunohistochemical analysis of Nav1.1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
CPA2048-100ul - Nav1.1
Western blot analysis of Nav1.1 expression in SHSY5Y (A); mouse brain (B); PC12 (C) whole cell lysates.
75-023 - SCN1A
Whole brain immunohistochemistry
75-023 - SCN1A
Adult rat hippocampus immunohistochemistry
75-023 - SCN1A
73-023 - SCN1A
Whole brain immunohistochemistry
73-023 - SCN1A
Adult rat hippocampus immunohistochemistry
73-023 - SCN1A
TA326498 - SCN1A
IHC analysis of Nav1.1 in frozen sections of mouse brain extract using the antibody
TA329027 - SCN1A
Western blot analysis of rat brain membranes: 1. Anti-Nav1.1 antibody , (1:200). 2. Anti-Nav1.1 antibody, preincubated with the control peptide antigen.
TA329027 - SCN1A
Expression of Nav1.1 in mouse cerebellum. Immunohistochemical staining of mouse cerebellum using Anti-Nav1.1 antibody . A. The distribution of Nav1.1 (red) forms a band (arrows) in the molecular layer (Mol), close to the Purkinje cell bodies. B. Purkinje nerve cells are stained with mouse anti-Parvalbumin (green). C. Confocal merge of Nav1.1 and Parvalbumin.
TA329027 - SCN1A
Expression of Nav1.1 in rat DRG cells Immunocytochemical staining of Paraformaldehyde-fixed and permeabilized rat dorsal root ganglion (DRG) using Anti-Nav1.1 antibody , (1:200), followed by goat anti-rabbit-AlexaFluor-555 secondary antibody. Nuclear staining of cells using the cell-permeable dye Hoechst 33342.
TA329029 - SCN1A
Western blot analysis of rat brain membranes: 1. Anti-Pan Nav antibody , (1:200). 2. Anti-Pan Nav antibody, preincubated with the control peptide antigen.
TA329029 - SCN1A
Expression of Nav channels in rat cerebellum. Immunohistochemical staining of rat cerebellum using Anti-Pan Nav antibody . A. Nav channels (red) appear in Purkinje cell bodies (vertical arrows) and in cells of the molecular layer (Mol), (horizontal arrows). B. Staining of Parvalbumin (green) in the same brain section. C. Confocal merge of Nav channels and Parvalbumin demonstrates the location of Nav channels to the cell body of Purkinje neurons.
TA341179 - SCN1A
Anti-SCN1A / Nav1.1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
TA347473 - SCN1A
Western blot analysis on HuvEc cell lysate using Sodium Channel-pan Antibody
TA354083 - SCN1A
Human Brain stained with anti-Sodium Channel-pan antibody.

9 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SCN1A antibody
  Mouse Monoclonal Anti-Nav1.1 Antibody  
IHC analysis of Nav1.1 in frozen sections of mouse brain extract using the antibody Mouse IgG1 S74-71 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €410.00
  OriGene Technologies, Inc.

SCN1A antibody
  Rabbit polyclonal Anti-NaV1.1  
Western blot analysis of rat brain membranes: 1. Anti-Nav1.1 antibody , (1:200). 2. Anti-Nav1.1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €585.00
  OriGene Technologies, Inc.
+2 additional images

SCN1A antibody
  Rabbit polyclonal Anti-Pan NaV  
Western blot analysis of rat brain membranes: 1. Anti-Pan Nav antibody , (1:200). 2. Anti-Pan Nav antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €585.00
  OriGene Technologies, Inc.
+1 additional image

SCN1A antibody
  Rabbit Polyclonal Anti-SCN1A Antibody (N-Terminus)  
Anti-SCN1A / Nav1.1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Ze
50 µg / €425.00
  OriGene Technologies, Inc.

SCN1A antibody
  Rabbit Polyclonal Anti-Sodium Channel-pan Antibody  
Western blot analysis on HuvEc cell lysate using Sodium Channel-pan Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €335.00
  OriGene Technologies, Inc.

SCN1A antibody
Whole brain immunohistochemistry Mouse IgG1 K74/71 Supernatant Hu, Ms, Rt C, ICC/IF, IP, WB
5 ml / €490.00
  Antibodies Incorporated
+2 additional images

NeuroMab

SCN1A antibody
Whole brain immunohistochemistry Mouse IgG1 K74/71 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €570.00
  Antibodies Incorporated
+2 additional images

NeuroMab

SCN1A antibody
Pancreas stained in IHC-P with SCN1A antibody Rabbit Purified Hu, Ms, Rt C, E, WB
0.1 mg / €450.00
  OriGene Technologies GmbH

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SCN1A (Myc-DDK tagged) - Human sodium channel, voltage-gated, type I, alpha subunit (SCN1A), transcript variant 1, 200 uL, >10^7 TU/mL
Lenti ORF particles, SCN1A (Myc-DDK tagged) - Human sodium channel, voltage-gated, type I, alpha subunit (SCN1A), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,420.00
  OriGene Technologies, Inc.
 

9 Item(s)

per page

Available Filters

Product Type
  1. Human Lenti ORF Particle (1)
  2. Primary Antibody (8)
Clonality
  1. Polyclonal (5)
  2. Monoclonal (3)
Target
  1. SCN1A (8)
Reactivity
  1. Human (Hu) (8)
  2. Mouse (Ms) (7)
  3. Rat (Rt) (7)
  4. Zebrafish (Ze) (1)
Applications
  1. Western blot / Immunoblot (WB) (7)
  2. Frozen sections (C) (4)
  3. Immunocytochemistry/​Immunofluorescence (ICC/IF) (3)
  4. Immunoprecipitation (IP) (2)
  5. Enzyme Immunoassay (E) (1)
Presentation
  1. Purified (7)
  2. Supernatant (1)
Host
  1. Rabbit (5)
  2. Mouse (3)
Images
  1. 1 image (8)
  2. 3+ images (3)
Images: Applications
  1. IHC (4)
  2. Western blot / Immunoblot (WB) (3)
  3. Frozen sections (C) (2)
  4. Immunofluorescence (IF) (1)
  5. Paraffin Sections (P) (1)
Manufacturer
  1. OriGene Technologies (7)
  2. Antibodies Incorporated (2)
Service
  • OriGene Technologies GmbH
  • Schillerstraße 5
  • D-32052 Herford
  • Germany
  • phone: +49-5221-34606-0
  • free call: 0800-227 47 46 (Germany only)
  • fax: +49-5221-34606-11
  • email: info-de@origene.com
  • orders: ordering-de@origene.com
 
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