SPTLC1 antibody
Principal name
SPTLC1 antibody
Alternative names for SPTLC1 antibody
Serine palmitoyltransferase 1, SPT 1, SPT1, LCB 1, LCB1, Serine-palmitoyl-CoA transferase 1, Long chain base biosynthesis protein 1
Gene ID
10558 (SPTLC1)
Ncbi ID
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P)
Background of SPTLC1 antibody
Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5\'-phosphate as a cofactor. SPTLC1 is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in SPTLC1 gene were identified in patients with hereditary sensory neuropathy type 1. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5\'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified.
General readings
1. Dawkins, J. L., Hulme, D. J., Brahmbhatt, S. B., Auer-Grumbach, M., Nicholson, G. A.Mutations in
SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary
sensory neuropathy type I.Nature Genet. 27: 309-312, 2001.
2. McCampbell, A., Truong, D., Broom, D. C., Allchorne, A., Gable, K., Cutler, R. G., Mattson, M. P.,
Woolf, C. J., Frosch, M. P., Harmon, J. M., Dunn, T. M., Brown, R. H., Jr.Mutant SPTLC1 dominantly
inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy.Hum.
Molec. Genet. 14: 3507-3521, 2005.
3. Verhoeven, K., Coen, K., De Vriendt, E., Jacobs, A., Van Gerwen, V., Smouts, I., Pou-Serradell, A.,
Martin, J.-J., Timmerman, V., De Jonghe, P.SPTLC1 mutation in twin sisters with hereditary sensory
neuropathy type I.Neurology 62: 1001-1002, 2004.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA319826 | SPTLC1 (C-term) antibody |
||||||
| Rabbit Polyclonal SPT1 Antibody | |||||||
 |
Rabbit | Aff - Purified | Hu | E, WB |
0.1 mg /
€415.00
|
||
| OriGene Technologies, Inc. | |||||||
 +1 additional image |
|||||||
