TYK2 antibody
Principal name
TYK2 antibody
Alternative names for TYK2 antibody
JTK1, Non-receptor tyrosine-protein kinase TYK2
Gene ID
7297 (TYK2)
Ncbi ID
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))
Background of TYK2 antibody
Tyk 2 belongs to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions occurring downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, recruit STAT transcription factors to the cytokine receptor where Tyk 2 is associated. Tyk 2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulating transcription. The canonical JAK-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Cytokine induced pro-inflammatory responses are attractive targets for anti-inflammatory therapies, specifically at the level of Jak-STAT signaling.
Immunoperoxidase of monoclonal antibody to TYK2 on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml]
Immunofluorescence of monoclonal antibody to TYK2 on HeLa cell. [antibody concentration 10 ug/ml]
Western Blot analysis of TYK2 expression in transfected 293T cell line by TYK2 monoclonal antibody (M01), clone 6G12.Lane 1: TYK2 transfected lysate(133.7 KDa).Lane 2: Non-transfected lysate.
TYK2 monoclonal antibody (M01), clone 6G12 Western Blot analysis of TYK2 expression in HeLa ( Cat # L013V1 ).
Immunoperoxidase of monoclonal antibody to TYK2 on formalin-fixed paraffin-embedded human leiomyosarcoma. [antibody concentration 3 ug/ml]
Immunofluorescence of monoclonal antibody to TYK2 on HeLa cell. [antibody concentration 10 ug/ml]
TYK2 monoclonal antibody (M02), clone 5A4 Western Blot analysis of TYK2 expression in Hela NE ( Cat # L013V3 ).
Immunoperoxidase of monoclonal antibody to TYK2 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]
Immunoperoxidase of monoclonal antibody to TYK2 on formalin-fixed paraffin-embedded human lymphoma. [antibody concentration 3 ug/ml]
TYK2 monoclonal antibody (M03), clone 6H1 Western Blot analysis of TYK2 expression in Hela NE ( Cat # L013V3 ).
Detection limit for recombinant GST tagged TYK2 is approximately 1ng/ml as a capture antibody.
Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using TYK2 antibody AP02648PU.
Kidney: Formalin-Fixed Paraffin-Embedded (FFPE)
Figure 1. Western blot analysis of extracts from HT-29 cells untreated or treated with Anisomycin (20min), using TYK2 (pTyr1054) antibody AP08010PU (Lane 1 and 2).
TYK2 MaxPab rabbit polyclonal antibody. Western Blot analysis of TYK2 expression in mouse spleen.
Western Blot analysis of TYK2 expression in transfected 293T cell line (H00007297-T02) by TYK2 MaxPab polyclonal antibody.Lane 1: TYK2 transfected lysate(133.70 KDa).Lane 2: Non-transfected lysate.
Western blot analysis of extracts from HT-29 cells treated with anisomycin ( 20 min ) , using TYK2 (phospho Y1054) polyclonal antibody ( Cat # PAB7734 ).
Immunohistochemistry (IHC) analyzes of Tyk 2 antibody (Cat.-No.: AP21083PU-N) in paraffin-embedded human breast carcinoma tissue.
Western blot (WB) analysis of Tyk 2 antibody (Cat.-No.: AP21083PU-N) in extracts from 293cells.
Human COLO205; WB Suggested Anti-TYK2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: COLO205 cell lysate; TYK2 antibody - C-terminal region (ARP30319_P050) in Human COLO205 cells using Western Blot
Western blot analysis using TYK2 antibody Cat.-No AM06139SU-N against truncated TYK2 recombinant protein (Lane 1) and Jurkat cell lysate (Lane 2).
Sample(30 ug whole cell lysate). A:H1299. B:HeLa S3. 5% SDS PAGE. TA308735 diluted at 1:1000
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using TYK2(TA308735) antibody at 1:200 dilution.
Western blot analysis of TYK2 in human small intestine tissue lysate with TYK2 antibody at (A) 1 and (B) 2 ug/mL
Predicted band size: 134 kDa . Positive control: Raji cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)
Western blot analysis of TYK2 expression in 293 cel
WB Suggested Anti-TYK2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: COLO205 cell lysate
Western blot analysis of extracts from HT29 cells untreated (Lane 1) or treated (Lane 2) with Anisomycin (20min), using TYK2 (phospho-Tyr1054) antibody.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA308735 | TYK2 antibody |
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| Rabbit polyclonal antibody to TYK2 (tyrosine kinase 2) | |||||||
 |
Rabbit | IgG | Aff - Purified | Hu | ICC/IF, WB |
0.1 ml /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
 +1 additional image |
|||||||
| TA309989 | TYK2 antibody |
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| Rabbit anti-TYK2 (Phospho-Tyr1054) polyclonal antibody(Phospho-specific) | |||||||
 |
Rabbit | IgG | Purified | Hu, Ms | WB |
0.1 mg /
€355.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA319732 | TYK2 antibody |
||||||
| Rabbit Polyclonal TYK2 Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 mg /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA321570 | TYK2 antibody |
||||||
| Anti-TYK2 Rabbit Polyclonal Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 ml /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| TA347921 | TYK2 antibody |
||||||
| Rabbit Polyclonal Anti-TYK2 Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu | WB |
0.1 mg /
€335.00
|
|
| OriGene Technologies, Inc. | |||||||
| AM06139SU-N | TYK2 antibody |
||||||
 |
Mouse | IgG1 | 8G8E9 | Ascites | Hu | E, WB |
0.1 ml /
€420.00
|
| OriGene Technologies GmbH | |||||||
| AP02648PU-N | TYK2 antibody |
||||||
 |
Rabbit | Aff - Purified | P |
0.1 mg /
€300.00
|
|||
| OriGene Technologies GmbH | |||||||
| AP02648PU-S | TYK2 antibody |
||||||
|
Rabbit | Aff - Purified | P |
50 µg /
€230.00
|
|||
| OriGene Technologies GmbH | |||||||
| AP08010PU-N | TYK2 pTyr1054 antibody |
||||||
 |
Rabbit | Aff - Purified | Hu, Ms, Rt | WB |
0.1 mg /
€300.00
|
||
| OriGene Technologies GmbH | |||||||
| AP08010PU-S | TYK2 pTyr1054 antibody |
||||||
|
Rabbit | Aff - Purified | Hu, Ms, Rt | WB |
50 µg /
€230.00
|
||
| OriGene Technologies GmbH | |||||||
| AP21083PU-N | TYK2 antibody |
||||||
 |
Rabbit | Aff - Purified | Hu, Ms | ICC/IF, P, WB |
0.1 mg /
€370.00
|
||
| OriGene Technologies GmbH | |||||||
| +1 additional image |
|||||||
CRISPR
| Catalog No. | Species | Donor Vector | |
|---|---|---|---|
| KN204351 | TYK2 - human gene knockout kit via CRISPR |
||
 |
Human | GFP-Puro |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN204351BN | TYK2 - human gene knockout kit via CRISPR |
||
|
Human | mBFP-Neo |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN204351LP | TYK2 - human gene knockout kit via CRISPR |
||
|
Human | Luciferase-Puro |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN204351RB | TYK2 - human gene knockout kit via CRISPR |
||
|
Human | RFP-BSD |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||